[Comparative evaluation of antioxidant properties of neoselen and berberin in chronic heliotrinal hepatitis]. / Sravnitel'naia otsenka antioksidantnykh svoistv neoselena i berberina pri khonicheskom geliotrinovom gepatite.

Prominent features of heliotrin-related chronic toxical disorders of the liver developing in hepatic cirrohosis include hyperfermentemia, hypoproteinemia, intensification of lipid peroxidation (LPO), as evidenced by decrease in the activity of the antioxidant defence. In chronic active liver disorders, hyperfermentemia and hyperlipoperoxidation are common, but it is later in the course of the experiment that hypoproteinemia and hypoalbuminemia and manifest depression of the antioxidant defence that come to be developing. Berberin experimental pharmacotherapy has been shown to attenuate the degree of hyperfermentemia, hyperlipoperoxidation and to increase levels of albumin and antioxidant defence enzymes, particularly so earlier in the course of the studies conducted but with aggravation of the pathological process the efficacy of the drug tended to be lower. Neoselen appeared to be effective in alleviating the cytologic syndrome, hyperlipoperoxidation, increasing the activity of the antioxidant defence enzymes. Patients are found to derive more benefit from neoselen therapy with prolongation of its use.

[The effect of perftoran on the morphofunctional status of the digestive system organs in experimental duodenal ulcer]. / Vliianie perftorana na morfo-funktsional'noe sostoianie organov pishchevaritel'noi sistemy pri éksperimental'noi iazve dvenadtsatiterstnoi kishki.

The authors studied the effect of perftoran (PF) on the morpho-functional parameters of alimentary system organs (ASO) (liver, pancreas, stomach, duodenum, and small intestine) in rats with experimental chronic acetate duodenal ulcer. Inflammatory-infiltrative and dystrophic changes were found in the ASO tissues which led to activation of the enzymes superoxide dismutase and catalase in their homogenates. PF pharmacotherapy reduces the inflammatory-infiltrative changes in the ASO tissues and normalizes the enzyme systems of antioxidant protection.

[The effect of phenazepam on the pancreatic excretory function in thermal stress]. / Vliianie fenazepama na vneshnesekretornuiu funktsiiu podzheludochnoi zhelezy pri teplovom stresse.

The excretory function of the pancreas was studied on albino rats during thermal stress and ACTH (corticotropine) administration. Stress inhibited the enzyme-synthesizing and enzyme-secreting functions of the gland. The tranquilizer phenazepam influencing the GABA-ergic brain systems exerted a protective effect on pancreatic exosecretion in stress and its strength depended on the administration regimen of the drug. Experiments with corticotropine have shown that the antistress effect of phenazepam, to a certain extent is related to its action on the level of ACTH production in the hypophysis.

[The efficacy of Kvamatel and Omez in correcting disorders of the antioxidant system of the digestive tract organs in experimental duodenal ulcer]. / Effektivnost' kvamatela i omeza v korrektsii narushenii antioksidantnoi sistemy organov pishchevaritel'nogo trakta pri éksperimental'noi iazve dvenadtsatiperstnoi kishki.

Experiments were performed on male albino rats with acetate duodenal ulcer to detect the changes in the activity of antioxidant protection enzymes--superoxydedismutase and catalase in the tissues of the liver, stomach, duodenum, and small intestine. The pronounced character of the changes depended on the degree of destruction and involvement of the intestinal system organs in the pathological process. Experimental quamatel or omez therapy corrected the detected changes in the antioxidant status of the tissues.

[Interrelationship between the structure, microcirculation and tissue-vascular permeability of the liver after experimental toxic damage]. / Vzaimootnosheniia struktury, mikrotsirkuliatsii i sosudisto-tkanevoi pronitsaemosti pecheni pri éksperimental'nom toksicheskom ee porazhenii

Biomicroscopic and morphological studies demonstrated that in experimental heliotrine affection of the liver there occurred very early and marked microcirculatory disturbances which preceded the parenchymal damage. With the further progress of the pathomorphological changes and chronization of the pathological process in the liver one of the leading roles was played by the advance of microcirculatory disturbances and of the tissue-vascular permeability leading to hypoxia of the hepatic tissue and derangement of the metabolic processes in the organ.