1.
Bioorg Med Chem Lett
; 17(23): 6572-5, 2007 Dec 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-17931866
RESUMEN
Replacement of the hydroxy cyclopentanone ring in PGE(2) with chemically more stable heterocyclic rings and substitution of the unsaturated alpha-alkenyl chain with a metabolically more stable phenethyl chain led to the development of potent and selective analogs of PGE(2). Compound 10f showed the highest potency and selectivity for EP(4) the receptor.