RESUMEN
The relationships between urinary 11-desoxy-17-oxo steroids (11-DOS), the ratio of 11-DOS to urinary 17-hydroxycorticosteroids (urinary discriminant ratio), plasma levels of the adrenal androgens dehydroepiandrosterone (DHA), DHA sulphate (DHAS), and 7 alpha-hydroxy DHA (7 alpha DHA), and tumour oestrogen receptor (ER) and progesterone receptor (PR) status were examined in pre, peri-, and postmenopausal women with breast cancer. Androgenic steroids and their metabolites decreased with age in women with breast cancer. In perimenopausal women there was a significant association of PR positive tumours and high androgen levels, whereas in postmenopausal women high androgen levels were associated with ER negative tumours. Survival was significantly related to plasma DHA level and tumour steroid receptor status. Thus, adrenal androgen levels below the group mean were associated with significantly decreased survival in women with postmenopausal receptor-positive tumours, and the association was particularly apparent in those who were axillary node negative. Since the number of patients studied was small these results should be regarded as provisional in nature. Nonetheless, the identification of this subgroup of node negative breast cancer women with reduced survival may be important when considering node negative patients for adjuvant therapy.
Asunto(s)
Andrógenos/metabolismo , Neoplasias de la Mama/metabolismo , Menopausia , Proteínas de Neoplasias/análisis , Receptores de Estrógenos/análisis , Receptores de Progesterona/análisis , 17-Hidroxicorticoesteroides/orina , Adulto , Anciano , Andrógenos/sangre , Andrógenos/orina , Neoplasias de la Mama/sangre , Neoplasias de la Mama/tratamiento farmacológico , Neoplasias de la Mama/mortalidad , Neoplasias de la Mama/cirugía , Neoplasias de la Mama/orina , Quimioterapia Adyuvante , Deshidroepiandrosterona/análogos & derivados , Deshidroepiandrosterona/sangre , Sulfato de Deshidroepiandrosterona , Femenino , Humanos , Metástasis Linfática , Persona de Mediana Edad , Nueva Zelanda/epidemiología , Posmenopausia , Premenopausia , Pronóstico , Modelos de Riesgos Proporcionales , Análisis de SupervivenciaRESUMEN
New Zealand top soils are low in selenium with some regional variation. Grain and cereal products are the main source of dietary selenium intake but in New Zealand their content is low due to widespread top soil deficiency. Whole blood levels reported from Oago, 68 +/- 13ng/ml, are a half to one-third of those in North America and also lower than in Auckland residents, 79 +/- 15.7ng/ml. The variation between New Zealanders is due to regional differences in top soil levels and grass content affecting secondary selenium sources such as sheep meat and beef. Regular consumption of selenium rich chicken and fish is associated with a significant increase above average values, but age, sex, smoking, alcohol and the use of oral contraceptives, are unimportant factors.