Processing Magnoliae Officinalis Cortex with ginger juice: process optimization based on AHP-CRITIC weighting method and composition changes after processing / 中国中药杂志

The weight coefficients of appearance traits, extract yield of standard decoction, and total content of honokiol and magnolol were determined by analytic hierarchy process(AHP), criteria importance though intercrieria correlation(CRITIC), and AHP-CRITIC weighting method, and the comprehensive scores were calculated. The effects of ginger juice dosage, moistening time, proces-sing temperature, and processing time on the quality of Magnoliae Officinalis Cortex(MOC) were investigated, and Box-Behnken design was employed to optimize the process parameters. To reveal the processing mechanism, MOC, ginger juice-processed Magnoliae Officinalis Cortex(GMOC), and water-processed Magnoliae Officinalis Cortex(WMOC) were compared. The results showed that the weight coefficients of the appearance traits, extract yield of standard decoction, and total content of honokiol and magnolol determined by AHP-CRITIC weighting method were 0.134, 0.287, and 0.579, respectively. The optimal processing parameters of GMOC were ginger juice dosage of 8%, moistening time of 120 min, and processing at 100 ℃ for 7 min. The content of syringoside and magnolflorine in MOC decreased after processing, and the content of honokiol and magnolol followed the trend of GMOC>MOC>WMOC, which suggested that the change in clinical efficacy of MOC after processing was associated with the changes of chemical composition. The optimized processing technology is stable and feasible and provides references for the modern production and processing of MOC.

Study on irritation of calcium oxalate crystal in raw Pinellia ternata / 中国中药杂志

<p><b>OBJECTIVE</b>Confirm the irritation of needle-like calcium oxalate crystals in raw Pinellia ternata.</p><p><b>METHOD</b>Comparing the irritations of raw P. ternate containing calcium oxalate crystals, the raw P. ternate no containing calcium oxalate crystals, the pure needle-like calcium oxalate crystals isolated from raw P. ternata, the extracts of water and various solvents from raw P. ternate. by using the model of rabbits' eyes. Studying the quantity effect relationship of different concentration suspensions of needle-like calcium oxalate crystal isolated from raw P. ternate on rabbits' eyes. Observing the shape and appearance of calcium oxalate crystals in raw P. ternate and raw India Madder Root by the electro microscope and comparing their irritation degrees with the same contents of calcium oxalate crystals.</p><p><b>RESULT</b>Calcium oxalate crystals in raw P. ternata showed very strong irritation property. Under the same content of calcium oxalate crystals, the irritation of raw P. ternata and pure needle-like calcium oxalate crystals isolated from raw P. ternate had no significant difference. The concentrations of needle-like calcium oxalate crystals were do relative to the degree of irritation on rabbits' eyes and they showed undoubted quantity-effect relationship.</p><p><b>CONCLUSION</b>Calcium oxalate crystal is the irritation component in raw P. ternata.</p>

Process mechanism of Atractylodes macrocephala and conversion of sesquiterpenes / 中国中药杂志

<p><b>OBJECTIVE</b>To research the process mechanism of Atractylodes macrocephala and conversion of sesquiterpenes from it.</p><p><b>METHOD</b>The contents of atractylenolide I, II and III in the different processed herbal medicines were determined by HPLC. The conversion of the sesquiterpenes was proved by the separation of oxides of atractylone.</p><p><b>RESULT</b>The contents of atractylenolide I and III increased after frying, and at high temperature the content of atract ylenolide III decreased. After oxidation, atractylone converted to atractylenolide I, III and biatractylenolide, and atractylenolide III converted to atractylenolide II after dehydration when heated.</p><p><b>CONCLUSION</b>Atractylone can convert to atractylenolides during process of A. macrocephala, and the contents of each component are related to the level of process.</p>

Distinctive compound in Rhizome of Pinellia ternata / 中国中药杂志

<p><b>OBJECTIVE</b>To look for and determine the distinctive compound in Pinellia ternata.</p><p><b>METHOD</b>With TLC, HPLC, the distinctive compound was found and obtained by using the method of HPLC preparation. Its structure was elucidated by spectral analysis and physico-chemical properties.</p><p><b>RESULT</b>The compound was identified as inosine.</p><p><b>CONCLUSION</b>Inosine is the distinctive compound in Rhizome of P. ternata, and it was isolated from Banxia for the first time.</p>