RESUMEN
The growing number of deaths related to sepsis has become a major concern for past few years. Sepsis is a complex pathological reactions that is explained by series of host response to microbial insult. The resulted systemic reactions are manifested by early appearance of proinflammatory cytokines leading to hyperinflammatory phase which is followed by septic shock and death of the patient. The present study has revealed that antibiotics are not self-sufficient to control the complex mechanism of sepsis. Moreover prolonged and unnecessary administration of antibiotics may lead to antibiotic resistance to pathogens. In addition to this, immunosuppressive medications are selective and have targeted approach to certain study population. Drugs from herbal origin have shown to possess a mammoth of immunomodulatory potential by suppressing proinflammatory and anti-inflammatory cytokines exhibiting no or minimal unwanted secondary responses. Concomitantly, herbal plants tend to modulate oxidative stress level and haematological imbalance during inflammatory diseased conditions. Natural compounds have gained much attention for the treatment of several clinical complications. Considering the promising responses of medicinal plants with less/no side effects and easy procurement, comprehensive research on herbal plants to treat sepsis should be contemplated.
Asunto(s)
Antiinflamatorios/uso terapéutico , Agentes Inmunomoduladores/uso terapéutico , Fitoterapia , Extractos Vegetales/uso terapéutico , Plantas Medicinales , Sepsis/tratamiento farmacológico , Animales , Antibacterianos/aislamiento & purificación , Antibacterianos/uso terapéutico , Antiinflamatorios/aislamiento & purificación , Antioxidantes/aislamiento & purificación , Antioxidantes/uso terapéutico , Humanos , Agentes Inmunomoduladores/aislamiento & purificación , Extractos Vegetales/aislamiento & purificación , Plantas Medicinales/química , Sepsis/inmunología , Sepsis/metabolismo , Sepsis/microbiologíaRESUMEN
The crude ethanolic extract of Saracococca saligna was found to be cytotoxic and antibacterial but produced no platelet aggregation induced by ADP. Antibacterial activity of two known alkaloid, pachyaximine-A and saracodine was determined. Pachyaximine-A possessed significant antibacterial activity against Escherichia coli, Staphylococcus aureus, Corynebacterium diphtheriae and Corynebacterium pyrogenes. Saracodme showed moderate activity against Staphylococcus pyrogenes, Escherichia coli, Staphylococcus aureus, Corynebacterium diphtheriae, Shigella boydii and Klebsiella pneumoniae.