RESUMEN
The crude methanolic extracts of the leaves, stem bark, stem heart wood, root bark and root heart wood of Euroschinus papuanus and the fractions obtained on partitioning with petrol, dichloromethane (D), ethyl acetate (E) and butanol (B), exhibited a broad spectrum antibacterial activity. Fractionation drastically enhanced the activity. Excellent activity was demonstrated by the E fractions of stem heart wood, D of root bark, and E of root heart wood. Antifungal activity was exhibited by the B fractions of leaves, stem heartwood and root bark.
Asunto(s)
Anacardiaceae , Antibacterianos/farmacología , Antifúngicos/farmacología , Fitoterapia , Extractos Vegetales/farmacología , Antibacterianos/administración & dosificación , Antibacterianos/uso terapéutico , Antifúngicos/administración & dosificación , Antifúngicos/uso terapéutico , Bacterias Gramnegativas/efectos de los fármacos , Bacterias Grampositivas/efectos de los fármacos , Humanos , Pruebas de Sensibilidad Microbiana , Hongos Mitospóricos/efectos de los fármacos , Corteza de la Planta , Extractos Vegetales/administración & dosificación , Extractos Vegetales/uso terapéutico , Hojas de la Planta , Raíces de Plantas , MaderaRESUMEN
The crude methanolic extracts of the leaves, stem and root barks of Alstonia scholaris and Leea tetramera on partitioning (petrol, dichloromethane, ethyl acetate, butanol) gave fractions exhibiting improved and broader spectrum of antibacterial activity. Especially the butanol fractions of A. scholaris and the root bark of L. tetramera. None of the fractions were active against the fungi tested.
Asunto(s)
Alstonia , Antiinfecciosos/farmacología , Bacterias/efectos de los fármacos , Fitoterapia , Extractos Vegetales/farmacología , Vitaceae , Antiinfecciosos/administración & dosificación , Antiinfecciosos/uso terapéutico , Humanos , Pruebas de Sensibilidad Microbiana , Hongos Mitospóricos/efectos de los fármacos , Extractos Vegetales/administración & dosificación , Extractos Vegetales/uso terapéutico , Hojas de la Planta , Raíces de Plantas , Tallos de la PlantaRESUMEN
The crude methanolic extracts of the stem and root barks, stem and root heart-wood, leaves, fruits and seeds of Artocarpus heterophyllus and their subsequent partitioning with petrol, dichloromethane, ethyl acetate and butanol gave fractions that exhibited a broad spectrum of antibacterial activity. The butanol fractions of the root bark and fruits were found to be the most active. None of the fractions were active against the fungi tested.
Asunto(s)
Antiinfecciosos/farmacología , Artocarpus , Bacterias Gramnegativas/efectos de los fármacos , Bacterias Grampositivas/efectos de los fármacos , Fitoterapia , Extractos Vegetales/farmacología , Animales , Antibacterianos , Antiinfecciosos/administración & dosificación , Antiinfecciosos/uso terapéutico , Frutas , Humanos , Pruebas de Sensibilidad Microbiana , Hongos Mitospóricos/efectos de los fármacos , Pruebas de Sensibilidad Parasitaria , Extractos Vegetales/administración & dosificación , Extractos Vegetales/uso terapéutico , Hojas de la Planta , Raíces de Plantas , Tallos de la Planta , Semillas , Trichomonas vaginalis/efectos de los fármacosRESUMEN
A broad spectrum of antibacterial activity was exhibited by the methanol extracts of leaves, root and stem barks of Terminalia complanata and Flacourtia zippelii and their subsequent fractions (petrol, dichloromethane, ethyl acetate). Fractionation enhanced the activity particularly in the ethyl acetate fractions of the stem and root barks of T. complanata. No activity was observed against the moulds.
Asunto(s)
Antiinfecciosos/farmacología , Extractos Vegetales/farmacología , Salicaceae/química , Terminalia/química , Animales , Antibacterianos , Antiinfecciosos/química , Eucariontes/efectos de los fármacos , Hongos/efectos de los fármacos , Bacterias Gramnegativas/efectos de los fármacos , Bacterias Grampositivas/efectos de los fármacos , Extractos Vegetales/químicaRESUMEN
The methanol extracts of leaves, root and stem barks of Calophyllum soulattri were partitioned with petrol, dichloromethane, ethyl acetate. The extracts demonstrated a range of antibacterial activity, improved on fractionation. None were found to be active against the moulds.
Asunto(s)
Antiinfecciosos/farmacología , Calophyllum/química , Extractos Vegetales/farmacología , Animales , Antibacterianos , Antiinfecciosos/química , Eucariontes/efectos de los fármacos , Hongos/efectos de los fármacos , Bacterias Gramnegativas/efectos de los fármacos , Bacterias Grampositivas/efectos de los fármacos , Extractos Vegetales/química , Estructuras de las Plantas/químicaRESUMEN
The methanol extracts of leaves, seeds, stem and root barks, stem and root heart-woods of Michelia champaca and the obtained fractions (petrol, dichloromethane, ethyl acetate, butanol) exhibited a broad spectrum of antibacterial activity. Fractionation drastically enhanced the level of activity particularly in all fractions of the stem bark and dichloromethane fraction of the root bark. Some fractions of the leaves, stem and root barks demonstrated antifungal activity against some of the tested moulds. Liriodenine was the active constituent of the root bark, with a broader and, in some cases, better level of activity as compared to the standard.
Asunto(s)
Antiinfecciosos/farmacología , Magnoliaceae/química , Extractos Vegetales/farmacología , Animales , Antibacterianos , Antiinfecciosos/química , Eucariontes/efectos de los fármacos , Hongos/efectos de los fármacos , Bacterias Gramnegativas/efectos de los fármacos , Bacterias Grampositivas/efectos de los fármacos , Estructura Molecular , Extractos Vegetales/química , Estructuras de las Plantas/químicaRESUMEN
The methanol extracts of leaves, root and stem barks of Psychotria microlabastra showed a broad spectrum of antibacterial activity, that was increased on fractionation (petrol, dichloromethane, ethyl acetate), particularly in the ethyl acetate fractions. None of the extractives showed activity against the tested moulds.
Asunto(s)
Antiinfecciosos/farmacología , Bacterias/efectos de los fármacos , Eucariontes/efectos de los fármacos , Hongos/efectos de los fármacos , Fitoterapia , Extractos Vegetales/farmacología , Rubiaceae , Animales , Antibacterianos , Antiinfecciosos/uso terapéutico , Humanos , Pruebas de Sensibilidad Microbiana , Extractos Vegetales/uso terapéutico , Estructuras de las PlantasRESUMEN
The methanol extracts of leaves, root and stem barks of Symplocos cochinchinensis and their fractions obtained by partition (petrol, dichloromethane, ethyl acetate) were screened for antimicrobial activity. All the crude extracts and fractions showed a broad spectrum of antibacterial activity, that was enhanced on fractionation. None of them showed activity against the tested moulds.
Asunto(s)
Antiinfecciosos/farmacología , Bacterias/efectos de los fármacos , Eucariontes/efectos de los fármacos , Hongos/efectos de los fármacos , Magnoliopsida , Fitoterapia , Extractos Vegetales/farmacología , Animales , Antibacterianos , Antiinfecciosos/uso terapéutico , Humanos , Pruebas de Sensibilidad Microbiana , Extractos Vegetales/uso terapéutico , Estructuras de las PlantasRESUMEN
The ethanol extracts of Bidens pilosa (whole plant), Bischofia javanica (leaves), Elmerillia papuana (root bark) and Sigesbekia orientalis (whole plant) were partitioned (petrol, dichloromethane, ethyl acetate). The crude ethanolic extracts and all the obtained fractions showed a broad spectrum of antibacterial activity, the ethyl acetate fractions and the petrol fraction of E. papuana being the most effective. No activity was observed against the tested moulds.
Asunto(s)
Antiinfecciosos/farmacología , Antiprotozoarios/farmacología , Asteraceae , Euphorbiaceae , Magnoliaceae , Fitoterapia , Extractos Vegetales/farmacología , Animales , Antibacterianos , Hongos/efectos de los fármacos , Bacterias Gramnegativas/efectos de los fármacos , Bacterias Grampositivas/efectos de los fármacos , Humanos , Pruebas de Sensibilidad Microbiana , Pruebas de Sensibilidad Parasitaria , Corteza de la Planta/química , Hojas de la Planta/química , Trichomonas vaginalis/efectos de los fármacosRESUMEN
The methanol extracts of leaves, stem and root barks of Lithocarpus celebicus showed a broad spectrum of antibacterial activity which was increased on fractionation (petrol, dichloromethane, ethylacetate), particularly in the ethyl acetate fraction of the stem bark and petrol fraction of the root bark. None of the extractives was active against tested moulds.
Asunto(s)
Antiinfecciosos/farmacología , Fagaceae , Extractos Vegetales/farmacología , Animales , Antibacterianos , Hongos/efectos de los fármacos , Bacterias Gramnegativas/efectos de los fármacos , Bacterias Grampositivas/efectos de los fármacos , Humanos , Pruebas de Sensibilidad Microbiana , Pruebas de Sensibilidad Parasitaria , Corteza de la Planta/química , Estructuras de las Plantas/química , Trichomonas vaginalis/efectos de los fármacosRESUMEN
The methanol extracts of leaves, flowers, stem and root barks of Cassia alata showed a broad spectrum of antibacterial activity. The activity was increased on fractionation (petrol, dichloromethane, ethyl acetate), the dichloromethane fraction of the flower extract being the most effective. No activity was shown against tested moulds.
Asunto(s)
Antiinfecciosos/farmacología , Bacterias/efectos de los fármacos , Cassia , Hongos/efectos de los fármacos , Plantas Medicinales , Trichomonas vaginalis/efectos de los fármacos , Animales , Antibacterianos , Humanos , Pruebas de Sensibilidad Microbiana , Pruebas de Sensibilidad Parasitaria , Extractos Vegetales/farmacología , Hojas de la Planta , Tallos de la PlantaRESUMEN
The methanol extracts of Clematis papuasica leaves and stem bark and of Nauclea obversifolia leaves, stem and root barks showed awide spectrum of antibacterial activity which was increased on fractionation (petrol, dichloromethane, ethyl acetate), the ethyl acetate fractions being in all cases the most effective. None of the extractives was active against tested moulds.
Asunto(s)
Antiinfecciosos/farmacología , Bacterias/efectos de los fármacos , Hongos/efectos de los fármacos , Magnoliopsida , Plantas Medicinales , Trichomonas vaginalis/efectos de los fármacos , Animales , Antibacterianos , Humanos , Pruebas de Sensibilidad Microbiana , Pruebas de Sensibilidad Parasitaria , Extractos Vegetales/farmacología , Hojas de la Planta , Raíces de Plantas , Tallos de la PlantaRESUMEN
The methanol extracts of Picrasma javanica, leaves, seeds, stem and root barks were partitioned (petrol, dichloromethane, ethyl acetate, butanol). All obtained extracts and fractions showed a broad spectrum of antibacterial activity, while none was active against the tested moulds.
Asunto(s)
Antibacterianos/farmacología , Bacterias/efectos de los fármacos , Plantas Medicinales , Rosales , Humanos , Pruebas de Sensibilidad Microbiana , Extractos Vegetales/farmacología , Estructuras de las PlantasRESUMEN
The methanol extracts of leaves, root and stem barks of Horsfieldia helwigii and Melia azedarach showed a broad spectrum of antibacterial activity. The activity was increased on fractionation (petrol, dichloromethane, ethyl acetate), particularly in the petrol fraction of the leaves of H. helwigii and dichlorometane fraction of the stem bark of M. azedarach. No activity was shown against tested moulds.
Asunto(s)
Antibacterianos/farmacología , Bacterias/efectos de los fármacos , Plantas Medicinales , Rosales , Humanos , Pruebas de Sensibilidad Microbiana , Extractos Vegetales/farmacología , Estructuras de las PlantasRESUMEN
The ethanol extracts of Omalanthus nervosus leaves, stem and root barks, were partitioned (petrol, dichloromethane, ethyl acetate). In respect to crude extracts, all fractions demonstrated broader spectrum and higher levels of antibacterial activity, ethyl acetate fractions being in all cases the more active. No fraction was active against tested moulds.
Asunto(s)
Antiinfecciosos/farmacología , Euphorbiaceae , Bacterias Gramnegativas/efectos de los fármacos , Bacterias Grampositivas/efectos de los fármacos , Plantas Medicinales , Animales , Antibacterianos , Hongos/efectos de los fármacos , Humanos , Pruebas de Sensibilidad Microbiana , Extractos Vegetales/farmacología , Hojas de la Planta , Raíces de Plantas , Tallos de la Planta , Trichomonas vaginalis/efectos de los fármacosRESUMEN
The methanol extracts of Harpullia ramiflora, leaves, flowers, stem and root barks were partitioned (petrol, dichloromethane, ethyl acetate). In respect to crude extracts, all fractions demonstrated broader spectrum and higher levels of antibacterial activity. The ethyl acetate fraction of the flowers exhibited the highest activity. No activity was shown against the tested moulds.
Asunto(s)
Antiinfecciosos/farmacología , Bacterias Gramnegativas/efectos de los fármacos , Bacterias Grampositivas/efectos de los fármacos , Plantas Medicinales , Rosales , Animales , Antibacterianos , Hongos/efectos de los fármacos , Humanos , Pruebas de Sensibilidad Microbiana , Extractos Vegetales/farmacología , Hojas de la Planta , Raíces de Plantas , Tallos de la Planta , Trichomonas vaginalis/efectos de los fármacosRESUMEN
The methanol extracts of Castanopsis acuminatissima leaves, stem and root barks were partitioned (petrol, dichloromethane, ethyl acetate). Though all of the crude methanolic extracts and obtained fractions from them, showed a broad spectrum of antibacterial activity, in most cases the activity was decreased on fractionation. None was active against tested moulds.
Asunto(s)
Antibacterianos/farmacología , Bacterias Gramnegativas/efectos de los fármacos , Bacterias Grampositivas/efectos de los fármacos , Plantas Medicinales , Rosales , Trichomonas vaginalis/efectos de los fármacos , Animales , Humanos , Pruebas de Sensibilidad Microbiana , Extractos Vegetales/farmacología , Hojas de la Planta , Raíces de Plantas , Tallos de la PlantaRESUMEN
A crude extract prepared from Scutellaria barbata D. Don (Lamiaceae) was analyzed in the effort to discover antibacterial compounds against high-level strains of methicillin-resistant Staphylococcus aureus (MRSA). Apigenin and luteolin were isolated from the plant as active constituents against the bacteria. These flavonoid congeners were selectively toxic to S. aureus, including the MRSA and methicillin-sensitive S. aureus strains.
Asunto(s)
Antibacterianos/aislamiento & purificación , Flavonoides/aislamiento & purificación , Lamiaceae/química , Resistencia a la Meticilina , Staphylococcus aureus/efectos de los fármacos , Antibacterianos/farmacología , Secuencia de Bases , Cartilla de ADN , Flavonoides/farmacología , Pruebas de Sensibilidad MicrobianaRESUMEN
The methanol extracts of Evodia elleryana, leaves, stem wood, stem bark, root wood and root bark were partitioned (petrol, dichloromethane, ethyl acetate). All obtained fractions showed a broad spectrum of antibacterial activity, while none were active against tested moulds.
Asunto(s)
Antiinfecciosos/farmacología , Bacterias/efectos de los fármacos , Hongos/efectos de los fármacos , Plantas Medicinales , Rosales , Antibacterianos , Humanos , Pruebas de Sensibilidad Microbiana , Extractos Vegetales/farmacología , Estructuras de las PlantasRESUMEN
We evaluated the effects of angiotensin II and an angiotensin-converting enzyme inhibitor (cilazapril) on nerve blood flow (NBF) and electrophysiology in control and diabetic rats. When applied locally to the sciatic nerve, the dose-response curve of angiotensin II was more potent in experimental diabetic neuropathy (EDN) than control rats. No difference existed in plasma angiotensin II levels between EDN and controls. The rats were given typical rat pellets or pellets treated with 10 mg/kg per day cilazapril for 4 weeks. Diabetes caused a significant reduction in NBF, nerve conduction velocity, and compound muscle action potential (CMAP) amplitudes. NBF was significantly increased in diabetic rats supplemented with cilazapril diet, and nerve conduction velocity and amplitudes of the CMAP were also improved after 4 weeks on this diet. Direct application 10(-3) mol/L cilazapril on sciatic nerve did not increase NBF in normal and EDN rats. We topically applied the nitric oxide synthase (NOS) inhibitor, NG-nitro-L-arginine, on sciatic nerve and observed reduced inhibition of NBF in EDN, which was correctable with a cilazapril diet. These results suggest that diabetic neuropathy may have an increasing vasopressor action with angiotensin II and this is likely to be the mechanism of NOS inhibition. Angiotensin II-converting enzyme inhibitors may have potential in the treatment of diabetic neuropathy.