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Antiviral Res ; 34(3): 113-9, 1997 May.
Artículo en Inglés | MEDLINE | ID: mdl-9191018

RESUMEN

Antiviral effects of nucleoside analogues against human adenoviruses (ADV) belonging to subgroup B (ADV3) and C (ADV2) were comparatively analysed using focus reduction assay on Fogh and Lund (FL) cells. 3'-Fluoro-2'-deoxythymidine (FTdR), 3'-fluoro-2'-deoxyuridine (FUdR), 2',3'-dideoxycytidine (ddC) and 3'-fluoro-2'-deoxyguanosine (FGdR) emerged as potent and selective inhibitors. They were nontoxic for the FL cells at the tested doses. FTdR was proved to be the most effective inhibitor against both serotypes ADV2 and ADV3 (0.05 microM/0.02 microM). The inhibitory effect of FTdR was also analyzed on the level of viral proteins and viral DNA synthesis using radioimmunoprecipitation and PCR, respectively. Neither the main structural protein of ADV, the hexon, nor viral DNA could be detected in ADV-infected FL cells that had been exposed to FTdR.


Asunto(s)
Adenovirus Humanos/efectos de los fármacos , Antivirales/farmacología , Didesoxinucleósidos/farmacología , Adenovirus Humanos/genética , Adenovirus Humanos/fisiología , Antivirales/química , Secuencia de Bases , Línea Celular , Cartilla de ADN/genética , ADN Viral/biosíntesis , ADN Viral/genética , Desoxiguanosina/análogos & derivados , Desoxiguanosina/farmacología , Didesoxinucleósidos/química , Evaluación Preclínica de Medicamentos , Floxuridina/farmacología , Humanos , Reacción en Cadena de la Polimerasa , Replicación Viral/efectos de los fármacos , Zalcitabina/farmacología
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