RESUMEN
Eighty-two multiparous Holstein cows were enrolled 28 d before expected calving and assigned to 1 of 4 dietary treatments in a randomized block design experiment with a 2 × 2 factorial arrangement of treatments to determine the effect of feeding a neutral or acidogenic diet varying in Ca concentration on prepartum and postpartum intake, blood mineral and metabolite concentrations, and postpartum milk production. Prepartum diets were formulated to provide a dietary cation-anion difference (DCAD) of -21 (negative, NEG) or -2 (neutral, NEU) mEq/100 g of dry matter with either 1.3% or 1.8% Ca. After calving, cows remained on trial through 63 d in milk (DIM) and were fed a common lactation diet. Urine pH was lower for NEG compared with NEU and tended to be lower for 1.8% Ca compared with 1.3% Ca. Fractional excretion of Ca and Mg in urine was greater for NEG than for NEU. Prepartum plasma bicarbonate was lower and P was higher for NEG compared with NEU. Prepartum plasma P and blood urea nitrogen to creatinine ratio was higher for 1.3% compared with 1.8% Ca. Postpartum, concentrations of plasma total protein, albumin, blood urea nitrogen, Mg, and ionized Mg (iMg) were higher and Na was lower for NEU compared with NEG. An interaction of DCAD and Ca was observed for plasma creatinine, which was highest for cows fed NEU and 1.3% Ca compared with all other treatments. Interactions of DCAD and DIM were observed for plasma bicarbonate and iMg. Bicarbonate was higher at 3 DIM and lower at 14 DIM for NEU compared with NEG. Concentrations of iMg were higher at 1, 2, and 14 DIM for NEU compared with NEG. Interactions of Ca and DIM were observed for plasma Ca, Cl, and anion gap. Compared with cows fed 1.5% Ca, those fed 1.3% Ca had lower Ca and anion gap and higher Cl at 1 DIM and lower Cl and higher anion gap at 14 DIM. No differences were observed in body weight or body condition score due to DCAD or Ca. Prepartum dry matter intake (DMI) was lower for NEG compared with NEU and lower for 1.8% compared with 1.3% Ca. Postpartum DMI was not different among treatments. An interaction was observed for DCAD and DIM due to higher milk yield after 45 DIM for NEG compared with NEU. No differences were observed in milk component percentage or yield among treatments. There was an interaction of DIM and Ca for milk urea concentrations, which were higher at 5 wk and lower at 6 wk for 1.3% Ca compared with 1.8% Ca. These results suggest that feeding NEG prepartum alters plasma and urine mineral concentrations compared with feeding NEU and supports increased milk yield after 45 DIM. Feeding 1.8% Ca prepartum only improved plasma Ca at 1 DIM. Feeding either NEG or 1.8% Ca reduced DMI prepartum compared with NEU or 1.3% Ca.
Asunto(s)
Alimentación Animal , Calcio de la Dieta/farmacología , Bovinos , Leche/química , Alimentación Animal/análisis , Animales , Nitrógeno de la Urea Sanguínea , Peso Corporal , Industria Lechera , Suplementos Dietéticos , Femenino , Lactancia , Minerales/metabolismo , Paridad , Periodo Posparto , Embarazo , Distribución AleatoriaRESUMEN
Eighty-two multiparous Holstein cows were fed diets differing in dietary cation-anion difference (DCAD) and Ca concentrations in a randomized block design experiment beginning 4 wk before anticipated calving to determine the effects on colostrum yield and quality and acid-base balance and mineral status of newborn calves. Treatments were arranged as a 2 × 2 factorial to provide 2 DCAD [-22 mEq/100 g of dry matter (NEG) or -3 mEq/100 g of dry matter (NEU)] and 2 supplemental Ca concentrations (1.3 or 1.8% of dry matter). After calving, cows were milked within 2 to 8 h and colostrum yield was recorded. Calves were fed 200 g of IgG of a commercial colostrum replacer within 4 h of birth. No differences were observed in birth weight or dystocia score among treatments, which averaged 42.7 kg and 1.12, respectively. Colostrum yield was not different among treatments and averaged 8.75 kg. Colostrum quality, as measured using a Brix refractometer, was not affected by DCAD but was higher for 1.3% compared with 1.8% Ca: 21.58% and 19.87%, respectively. Colostrum IgG concentrations were higher for NEG compared with NEU and for 1.3% compared with 1.8% Ca. No differences were observed in concentrations of serum IgG, Ca, P, K, Cl, anion gap, or whole-blood pH, partial pressure of O2, or SO2 of calves among treatments. Serum Mg and lactate concentrations were higher and CO2 tended to be lower for calves born to cows fed 1.3% compared with 1.8% Ca. Interactions of DCAD and Ca were observed for serum Na and Cl, which were higher for NEU-1.3% Ca and NEG-1.8% Ca compared with NEU-1.8% Ca and NEG-1.3% Ca. Whole-blood partial pressure of CO2, and HCO3 exhibited an interaction of DCAD and Ca and tended to be lower for NEU-1.3% Ca and NEG-1.8% Ca compared with NEU-1.8% Ca and NEG-1.3% Ca. Results of this trial indicate that feeding prepartum diets with 1.8% compared with 1.3% supplemental Ca reduced colostrum quality and serum concentrations of Mg and lactate in calves immediately after birth. Feeding NEG supported higher colostrum IgG concentrations. Blood mineral concentrations and blood gas balance tended to differ, but the effects were not consistent across DCAD and Ca.
Asunto(s)
Análisis de los Gases de la Sangre/veterinaria , Calcio/administración & dosificación , Calcio/sangre , Bovinos/metabolismo , Calostro/química , Alimentación Animal , Animales , Animales Recién Nacidos , Aniones , Cationes , Dieta , Femenino , Concentración de Iones de Hidrógeno , Minerales , EmbarazoRESUMEN
Fifteen wethers (average BW 45.0 kg), fitted with abomasal and ileal cannulas, were fed a 70% concentrate diet alone or supplemented with 23 ppm of lasalocid or 23 ppm of monensin, DM basis. Wethers were fed 398 g of DM twice daily during a 10-d preliminary period, a 10-d total collection period, and a 6-d digesta collection period. During the total collection period, feed, feces, and urine were collected daily and composited. During the digesta collection, abomasal and ileal digesta and feces were collected at 12-h intervals, advancing 2 h each day, and composited. Feeding lasalocid and monensin increased (P < .01) urinary Mg excretion 17% and 19%, respectively. Lasalocid and monensin did not alter Ca and P metabolism. Feeding lasalocid decreased (P < .05) urinary excretion of Na 29%, whereas feeding monensin tended (P < .10) to increase it, compared with sheep fed the control diet. The effects of lasalocid and monensin were different for several variables compared with controls. Lasalocid and monensin altered absorption at different sites, overall absorption, and retention of minerals in sheep.
Asunto(s)
Absorción Intestinal/efectos de los fármacos , Lasalocido/farmacología , Minerales/farmacocinética , Monensina/farmacología , Ovinos/fisiología , Alimentación Animal , Animales , Digestión/efectos de los fármacos , Alimentos Fortificados , Tránsito Gastrointestinal/efectos de los fármacos , Intestino Grueso/metabolismo , Intestino Delgado/metabolismo , Lasalocido/administración & dosificación , Masculino , Monensina/administración & dosificación , Distribución AleatoriaRESUMEN
A study consisting of two trials was conducted to determine the effects of monensin on the apparent absorption and retention of magnesium (Mg), phosphorus (P), calcium (Ca) and zinc (Zn) and to determine mineral changes in tissue and ruminal fluid. Eight lambs (39 kg) were used in trial 1, and 10 lambs (37 kg) were used in trial 2. Animals were blocked by weight and fed a high concentrate diet with or without 20 mg/kg monensin. Trials began with a dietary adjustment period lasting 18 d in trial 1 and 21 d in trial 2. Animals were then placed in metabolism stalls for a 10-d stall adjustment period followed by a 12-d collection period. Collections to determine mineral balance were made during the first 10 d of the collection period. Blood and ruminal fluid samples were taken on d 11 of the collection period. Lambs were slaughtered on d 12 of the collection period and tissue samples were collected. Monensin supplementation increased (P less than .05) Mg retention 42.0%. Urinary Ca excretion decreased (P less than .05) 60.0% when monensin was fed. Monensin supplementation decreased (P less than .05) liver Ca and bone Ca, 45.5 and 2.9%, respectively. Apparent P digestibility increased (P less than .05) 40.0% and P retention increased (P less than .10) 26.8% due to monensin supplementation. Both apparent absorption and retention of Zn increased (P less than .01) 50.0 and 45.0%, respectively, with monensin supplementation. Ruminal fluid Zn concentrations decreased (P less than .05) 33.0% with the addition of monensin.(ABSTRACT TRUNCATED AT 250 WORDS)
Asunto(s)
Calcio/metabolismo , Furanos/farmacología , Magnesio/metabolismo , Monensina/farmacología , Fósforo/metabolismo , Ovinos/metabolismo , Zinc/metabolismo , Animales , Aditivos Alimentarios , Jugo Gástrico/metabolismo , Absorción Intestinal/efectos de los fármacos , Masculino , Especificidad de Órganos , Rumen/metabolismo , Distribución TisularRESUMEN
Female Sprague-Dawley rats were fed two levels of phosphorus ad libitum and in a paired feeding arrangement to yield the following three treatments: adequate phosphorus (0.40%) ad libitum intake, low phosphorus (0.04%) ad libitum intake and adequate phosphorus pair-fed with the low phosphorus group. Feed intake, growth rate and feed conversion in rats fed 0.04% phosphorus ad libitum and in pair-fed control rats were lower (P less than 0.01) than in rats fed 0.40% phosphorus ad libitum. Seventy-five percent of the rats exhibited normal estrous cycles, as indicated by vaginal smears, throughout the 105-d period regardless of dietary phosphorus level. Breeding efficiency and number of pups per litter were not altered by dietary treatment. However, compared to either phosphorus-adequate group, dams fed 0.04% phosphorus weaned fewer (P less than 0.05) pups and pup survival to 45 d of age was lower (P less than 0.05). Average daily gain postweaning was 67% lower for pups in the phosphorus-deficient group than for those in either phosphorus-adequate group. Phosphorus deficiency in rats does not alter estrous cycles but reduces pup survivability postnatally.