The Effect of Auditory Residual Inhibition on Tinnitus and the Electroencephalogram.

OBJECTIVES: Tinnitus is the perception of sound in the absence of an external physical sound source, for some people it can severely reduce the quality of life. Acoustic residual inhibition (ARI) is a suppression of tinnitus following the cessation of a sound. The present study investigated the effect of ARI on brain activity measured using EEG. DESIGN: Thirty adult participants (mean age of 58 years) experiencing chronic tinnitus (minimum 2 years) participated. Participants were presented broad band noise at 10 dB above minimum masking level (1 min followed by 4 min of silence, 4 times) counterbalanced with a control treatment of broad band noise at threshold (1 min followed by 4 min of silence, 4 times) while 64-channel EEG was simultaneously recorded. Tinnitus loudness was measured using a 9-point tinnitus loudness rating scale. RESULTS: The ARI stimulation resulted in a self-reported reduction in tinnitus loudness in 17 of the 30 participants. Tinnitus rating reduced following stimulation but gradually returned to near baseline during 4 min of silence post sound exposure; successive sound exposures resulted in lower loudness ratings. No significant reductions in loudness rating were found with the control stimulation. The EEG showed increases in power spectral density, particularly in the alpha and gamma bands, during ARI compared to the control periods. CONCLUSIONS: These results contribute to the understanding of ARI and tinnitus. We recommend that there be a closer examination of the relationship between onset and offset of sound in both tinnitus and nontinnitus control participants to ascertain if EEG changes seen with ARI relate to tinnitus suppression or general postsound activity.

Auditory Streaming and Prediction in Tinnitus Sufferers.

OBJECTIVES: The aim of this study was to determine whether auditory streaming (segregation of incoming sounds into separate sound sources) and the ability to anticipate future auditory events are affected in tinnitus sufferers compared with nontinnitus controls with matched levels of hearing. It was hypothesized that tinnitus would result in abnormal electroencephalography responses to tone deviants and tone omissions compared to controls for frequencies near the pitch of tinnitus, and this should correspond with increased levels of cortical γ and θ oscillatory rhythms. DESIGN: Sixteen individuals with tinnitus (10 men and 6 women; age, 53.44; SD, 12.92 years) and 14 control participants (8 men and 6 women; age, 50.25; SD, 18.54 years) took part in the study. A modified version of the ABA streaming paradigm, with repeating triplet pattern of two frequencies (A and B) presented as A-B-A, was used to examine deviant-related prediction error. Omission-related prediction errors were examined using a modified version of a tone-omission paradigm. Regions of interest were frontocentral, left frontal, right frontal, and temporal lobes. RESULTS: A larger N1c waveform was elicited in the absence of any tone deviation within the left primary auditory cortex of tinnitus participants. No differences were present between groups for omissions. The only difference in oscillatory band activity between the two groups in this study was in response to tones 7 semitones different from tinnitus pitch, with significantly lower ß-2 band activity present for the tinnitus group, correlating most with activity within the right inferior occipital gyrus. CONCLUSIONS: The findings from this study imply that cortical-level auditory stream segregation is altered among individuals with tinnitus.

A feasibility study of predictable and unpredictable surf-like sounds for tinnitus therapy using personal music players.

OBJECTIVE: To evaluate the feasibility of predictable or unpredictable amplitude-modulated sounds for tinnitus therapy. DESIGN: The study consisted of two parts. (1) An adaptation experiment. Loudness level matches and rating scales (10-point) for loudness and distress were obtained at a silent baseline and at the end of three counterbalanced 30-min exposures (silence, predictable and unpredictable). (2) A qualitative 2-week sound therapy feasibility trial. Participants took home a personal music player (PMP). STUDY SAMPLE: Part 1: 23 individuals with chronic tinnitus and part 2: seven individuals randomly selected from Part 1. RESULTS: Self-reported tinnitus loudness and annoyance were significantly lower than baseline ratings after acute unpredictable sound exposure. Tinnitus annoyance ratings were also significantly lower than the baseline but the effect was small. The feasibility trial identified that participant preferences for sounds varied. Three participants did not obtain any benefit from either sound. Three participants preferred unpredictable compared to predictable sounds. Some participants had difficulty using the PMP, the average self-report hours of use were low (less <1 h/day). CONCLUSIONS: Unpredictable surf-like sounds played using a PMP is a feasible tinnitus treatment. Further work is required to improve the acceptance of the sound and ease of PMP use.

The performance of an automatic acoustic-based program classifier compared to hearing aid users' manual selection of listening programs.

OBJECTIVE: To compare preference for and performance of manually selected programmes to an automatic sound classifier, the Phonak AutoSense OS. DESIGN: A single blind repeated measures study. Participants were fit with Phonak Virto V90 ITE aids; preferences for different listening programmes were compared across four different sound scenarios (speech in: quiet, noise, loud noise and a car). Following a 4-week trial preferences were reassessed and the users preferred programme was compared to the automatic classifier for sound quality and hearing in noise (HINT test) using a 12 loudspeaker array. STUDY SAMPLE: Twenty-five participants with symmetrical moderate-severe sensorineural hearing loss. RESULTS: Participant preferences of manual programme for scenarios varied considerably between and within sessions. A HINT Speech Reception Threshold (SRT) advantage was observed for the automatic classifier over participant's manual selection for speech in quiet, loud noise and car noise. Sound quality ratings were similar for both manual and automatic selections. CONCLUSIONS: The use of a sound classifier is a viable alternative to manual programme selection.

Methodology for studying the transient effects of transcranial direct current stimulation combined with auditory residual inhibition on tinnitus.

BACKGROUND: Transcranial direct current stimulation (tDCS) and auditory residual inhibition (RI) are short lasting non-invasive techniques that can suppress tinnitus in some people. A pilot study was undertaken to evaluate methods to measure a potential additive effect of these treatments. NEW METHOD: Ten participants (mean age 59 years) with chronic tinnitus underwent four sessions of anodal tDCS of the left temporoparietal area(LTA) combined with 1min of auditory stimulation (broadband noise presented at tinnitus minimum masking level [MML]+10 dB), either before, during or immediately after tDCS and in a sham controlled session. Participants continuously monitored and recorded their MML on custom software prior to stimulation, during 20 min of tDCS, and 30 min following tDCS. A tinnitus loudness rating was undertaken before and after completion of testing. RESULTS: Nine out of ten participants completed the study, one participant dropped out after two sessions due to self-reported worsening in tinnitus symptoms. Seven out of nine participants reported transient tinnitus suppression when sound stimulation was presented along with tDCS. No reliable change in MML was observed. COMPARISON WITH EXISTING METHOD: This is the first study to examine the feasibility of continuously measuring MML while providing a combination of auditory and noninvasive brain stimulation simultaneously. CONCLUSIONS: We propose modifications in the protocol used, to find ways to increase the duration of auditory RI and investigate its underlying mechanisms. Recommendations for further research are discussed.

Prescription of hearing-aid output for tinnitus relief.

OBJECTIVE: Tinnitus is a perceived sound that cannot be attributed to an external source. This study attempts to identify a prescription of amplification that is optimized as a first-fit setting for tinnitus relief. DESIGN: Participants compared the effect of high frequency amplification on their tinnitus. Stimuli were 13 speech files with different amounts of high frequency amplification (three cut-off frequencies and four gain settings) to simulate the effects of a change in DSL(I/O) v5.0 prescription in the high frequencies. STUDY SAMPLE: Twenty-five participants with chronic tinnitus participated in the study. RESULTS: A 6-dB reduction to prescribed gain at 2 kHz emerged as the most preferred output (26.47% participants) to interfere with participants' tinnitus. Overall, 70.58% of the participants' preferred a 3 to 6 dB reduction in output while 29.42% preferred a similar increase across all cut-off frequencies. A trend was observed in which the higher the tinnitus pitch the more similar the preferred output to DSL(I/O) v5.0. CONCLUSION: DSL(I/O) v5.0 appears to be a good starting point for prescription of hearing-aid output for tinnitus management. Long-term benefits of different prescriptions for tinnitus still need to be ascertained.