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Métodos Terapéuticos y Terapias MTCI
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1.
Plant Cell Rep ; 41(11): 2187-2200, 2022 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-35984498

RESUMEN

KEY MESSAGE: Epidendrum produces 2n gametes with high frequency. This paper is the first to report on multiple pathways for forming 2n gametes, meiotic defeats, and pre-meiotic chromosome doubling. Unreduced 2n reproductive cells are predominantly involved in pathways that lead to polyploid plants. Although one of the most common pathways for inducing 2n gametes is through meiotic defects, a small set of isolated species alternatively generates 2n gametes from tetraploid pollen mother cells in the pre-meiotic phase. Hence, determining the mechanisms underlying 2n gamete formation is critical to improving breeding programmes and understanding plant evolution. We investigated sporads to reveal the pathway(s) accounting for the formation and frequencies of 2n gametes in wild species and interspecific hybrids in the genus Epidendrum. We investigated different types of sporads with varying frequencies, sizes, and viability in the wild species and hybrids of the genus Epidendrum. Large tetrad-estimated pre-meiotic chromosome doubling was observed in wild species. The Epidendrum is unique in that it forms 2n pollens via two pathways, namely, meiotic defects and pre-meiotic chromosome doubling. These two pathways of 2n pollen formation could influence the high diversity generation of polyploidy with different degrees of heterozygosity and genetic backgrounds in the genus Epidendrum. Therefore, these findings are proposed to influence polyploid breeding of Epidendrum via 2n pollen, helping us understand evolution and speciation via unreduced 2n gamete formation in Orchidaceae.


Asunto(s)
Fitomejoramiento , Poliploidía , Células Germinativas/metabolismo , Polen/genética , Tetraploidía , Plantas/genética , Meiosis/genética
2.
Anim Sci J ; 89(7): 1033-1039, 2018 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-29766599

RESUMEN

The objective of the present study was to evaluate the effectiveness of enrofloxacin (ERFX) as a second-line antibiotic for treatment of acute Escherichia coli (E. coli) mastitis. Forty-two cows with naturally occurring acute E. coli mastitis were enrolled. On the first day of treatment (day 0), empirically selected antibiotics (oxytetracycline: n = 32, kanamycin: n = 10) were administered. Although systemic signs improved in 10 cows (first-line group), the signs remained unchanged or worsened in 32 cows on day 1, including two cows that were found dead. The 30 surviving cows were randomly assigned to second-line groups constituting an ERFX group (n = 19) or a control group (n = 11) that was treated with other antibiotics. Response to each treatment was evaluated by measuring clinical signs from day 0 to day 3, subsequent quarter milk recovery, and the 60-day survival rate. Appetite on day 3 was significantly better in the ERFX group compared to the control group. No significant differences were observed in the 60-day survival rate or the subsequent milk recovery between the ERFX group and the control group. Thus, the use of ERFX as a second-line antibiotic for the treatment of acute E. coli mastitis could induce a rapid appetite recovery.


Asunto(s)
Antibacterianos/administración & dosificación , Enfermedades de los Bovinos/tratamiento farmacológico , Infecciones por Escherichia coli , Fluoroquinolonas/administración & dosificación , Mastitis/tratamiento farmacológico , Mastitis/microbiología , Mastitis/veterinaria , Retratamiento/métodos , Enfermedad Aguda , Animales , Apetito , Bovinos , Enfermedades de los Bovinos/fisiopatología , Progresión de la Enfermedad , Quimioterapia Combinada , Enrofloxacina , Femenino , Kanamicina/administración & dosificación , Mastitis/fisiopatología , Oxitetraciclina/administración & dosificación , Factores de Tiempo , Insuficiencia del Tratamiento , Resultado del Tratamiento
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