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Bioorg Med Chem Lett
; 11(17): 2397-9, 2001 Sep 03.
Artículo
en Inglés
| MEDLINE
| ID: mdl-11527740
RESUMEN
The synthesis and biological activities of a series of new 1beta-methylcarbapenems 1a-h having heteroaromatic thioether moiety at C-5 position of pyrrolidine were described. Among these compounds, 1,2,3-thiadiazole derivative 1h showed the most potent antibacterial activity and advanced pharmacokinetics in comparison with meropenem.