[Delayed Copying of Unfamiliar Contour Shapes: Analysis of Potentials Related to Stimuli].

The high-density EEG was recorded and ERPs related to showing unfamiliar contour shapes and delivering imperative signal (a short sound) were estimated in the task requiring delayed motor reproduction of these shapes. A total of 22 right-handed adults participated in the experiment. They performed 5-blocks of trials corresponding-to 5 different delays (T= 0; 500, 1000, 2000 4000 ms) between the imperative signal relative to the end of the contour trajectory presentation. An ERP analysis showed that, unlike ERPs related to the contour shape presentation, those related to the imperative signal delivery do change with growing delay T. A subsequent analysis of cortical sources of the ERPs related to the imperative stimulus showed corresponding pronounced grows of reactivity of orbito-frontal cortex of the right hemisphere and a symmetrical bilateral grows of reactivity of dorsal parts of the sensorimotor cortex. The reported findings are discussed in the framework of the proposal according to which the internal representation of a trajectory undergoes a transi- tion from a sensory-specific format towards more abstract neither sensory- nor motor-specific format.

[The corrective action of limontar in metabolic disorders in the mother-fetus system caused by ethanol exposure during pregnancy]. / Issledovanie korrigiruiushchego deistviia limontara pri obmennykh narusheniiakh v sisteme mat'--plod, vyzvannykh vozdeistviem étanola vo vremia beremennosti.

It was established in experiments on nonbred albino rats that injection of limontar (1 mg/kg) in the fetal period of pregnancy in alcoholic intoxication (6 g/kg) leads to weight loss by the female, normalization of the character of behavior and metabolic shifts in the organism, and removal of the symptoms of excitation of the sympathetic link of cardiovascular system regulation. No harmful effect of limontar on the mother-fetus biosystem was detected.

[New possibilities for metabolic protection from hypoxia in pregnant rats and their progeny]. / Novye vozmozhnosti metabolicheskoi zashchity ot gipoksii beremennykh krys i ikh potomstva.

Individual resistance of pregnant rats and the newborns to acute hypoxic hypoxia was studied. It was found that individual resistance of the organism to hypoxia significantly decreases in the last period of pregnancy. A new drug limontar proved to possess the properties of an active antihypoxia agent. Its administration during the last third of pregnancy stimulated the organism's protective-adaptational reactions, increased the resistance of pregnant, rats and the newborns to hypoxia. Limontar significantly improves the mechanometabolic indices of an isolated perfused heart under hypoxic conditions. Analysis of the obtained data suggests that limontar increases energy formation in the myocardium through activation of a more efficient and energetically beneficial path of succinic acid oxidation.

[The corrective properties of glycine in alcoholic intoxication in the fetal period of pregnancy]. / Korrigiruiushchie svoistva glitsina pri alkogol'noi intoksikatsii v plodnyi period beremennosti.

Natural metabolite glycine administered per os to rats in the fetus period of pregnancy in a dose of 1 mg/kg was found to exert a corrective action with respect to the toxic effect of ethanol in the mother-fetus system. Glycine prevents loss in the body weight, normalizes functional state of the nervous system and metabolic disorders in the maternal organism, improve the redox processes in the lymphocytes changed under alcoholization, and protect the fetus both on the metabolic and microstructural levels.

[The protective action of limontar in pregnant animals with acute hypoxic hypoxia]. / Protektornoe deistvie limontara na beremennykh zhivotnykh pri ostroi gipoksicheskoi gipoksii.

A comparative study of individual resistance of rats to acute hypoxic hypoxia was performed. It was shown that individual resistance of the organism to hypoxia significantly decreases in the course of pregnancy. Limontar is shown to be active antihypoxant. Limontar administered during the last third of pregnancy stimulates protective-adaptive reactions in the females, thus increasing their resistance to hypoxia.

[The use of glutathione as a protector agent in hypoxic exposure]. / Ispol'zovanie glutationa v kachestve protektornogo sredstva pri gipoksicheskom vozdeistvii.

The antihypoxic effect of glutathione was studied in a pressure chamber of acute hypoxic hypoxia and in the perfused heart of non-inbred rats. The body's natural metabolite glutathione was found to show the properties of an active antihypoxant, a protector of energy action. The mechanism of this action of glutathione may be associated with decreased hyper-recovery of the mitochondrial respiratory chain and with its restored capacity to synthesize ATP at the first point of oxidative phosphorylation.

[Quantum hemotherapy in the treatment of chronic postembolic pulmonary hypertension]. / Kvantovaia gemoterapiia pri lechenii khronicheskoi postémbolicheskoi legochnoi gipertenzii.

Based on studying 34 patients, the authors made a conclusion that transfusion of UVI autoblood improves the pulmonary blood circulation, increases blood oxygenation and deformability of erythrocytes, decreases blood viscosity.

[The correction of energy metabolism disorders in hypoxia by using vitamin K]. / Korrektsiia narushenii énergeticheskogo obmena pri gipoksii s pomoshch'iu vitamina K.

A study was made of the possibility of correcting respiratory chain function disorders in hypoxia by means of the naphthoquinone derivative vitamin K3. The antihypoxic activity of that compound is defined by its donor-acceptor properties and its capability to shunt the electron flow from NADH to CoQ. The effect is more pronounced in the tissues that oxidize mostly the NAD-dependent substrates which is related to rapid inactivation of the given enzymatic complex under hypoxia and correlates with low resistance of the cell using the NADH-oxidase pathway of oxidizing energy substrates to oxygen deficiency.

[The use of the perfused rat heart as a model for selecting antihypoxic compounds]. / Nekotorye aspekty ispol'zovaniia perfuziruemogo serdtsa krysy kak modeli dlia otbora antigipoksicheskikh soedinenii.

The test system for selection of antihypoxic compounds was developed and approved on the basis of the model of the perfused rat heart. It was found that the hypoxic state of the moderate degree of severity simulated on the myocardium is optimal for the assessment of the studied antihypoxic compounds. Taking into consideration the fact that at the early stages of hypoxia the electron transport is disordered at the level of the first enzymatic complex of the respiration chain, the protective actions of the agents (menadione and hydroquinone) being able of shunting the respiration chain to bypass the damaged area were studied. It was found that under hypoxia these compounds improve the energy-dependent contractile properties of the myocardium, that is, show up the antihypoxic effects.

[Changes in peripheral hemodynamics in patients with chronic circulatory insufficiency in the extremities after the treatment by reinfusion of UV-irradiated blood]. / Izmenenie perifericheskoi gemodinamiki u bol'nykh s khronicheskoi nedostatochnost'iu krovosnabzheniia konechnostei pri lechenii reinfuziei obluchennoi ul'trafioletovymi luchami krovi.

Reinfusion of the blood irradiated with the ultra-violet rays in patients with chronic insufficiency of the blood supply of the extremities leads to significant increase in the linear and volumetric blood flow rate in the damaged extremities, improvement in the microcirculation, reduction in the blood viscosity. The effect doesn't depend on the genesis of occlusion and degree of the impairement of circulation.

[Correction of blood hyperviscosity in patients with chronic post-embolic pulmonary hypertension by the method of infusion of UV-irradiated autologous blood]. / Korrektsiia giperviazkosti krovi u bol'nykh s khronicheskoi postémbolicheskoi legochnoi gipertenziei metodom infuzii UF-obluchennoi autokrovi.

Examination of 38 patients with chronic postembolic pulmonary hypertension revealed gross hemorheological disorders: increased viscosity of blood, extreme aggregation activity of blood cells, diminished property or erythrocytes to undergo deformity when circulating through the capillaries. Small amounts of UV-irradiated autologous blood were infused repeatedly for the correction of these disorders. After a course of treatment the hemorheological indices were normalized in all the patients, which was attended by improvement of the general condition and positive hemodynamic shifts.

[Transfusion of photomodified autologous blood as a method of correcting hypoxemic disorders in surgical patients]. / Transfuziia fotomodifitsirovannoi autokrovi kak metod korrektsii gipoksemicheskikh rasstroistv u khirurgicheskikh bo'lnykh.

An examination of 24 surgical patients has shown a positive influence of transfusion of photomodified blood upon the partial blood pressure in the arterial and venous blood, oxygen saturation of hemoglobin and arterio-venous oxygen difference. These data evidence the possibility to use the transfusion of photomodified autologous blood for correction of hypoxemia.

[Decreased activity of lipid peroxidation and thrombocyte aggregation in patients with chronic arterial insufficiency of the extremities after the treatment by the method of infusion of UV-irradiated blood]. / Snizhenie aktivnosti perekisnogo okisleniia lipidov i trombotsitarnoiagregatsii u bo'lnykh s khronicheskoi arteria'lnoi nedostatochnos'ti konechnostei pri lechenii metodom infuzii UF-obluchennoi krovi.

A correlation of the degree of increase of activity of lipid peroxidation with genesis and degree of the disease is considered. It was shown that a course of infusions of UV-irradiated autologous blood decreased the lipid peroxidation activity and inhibited thrombocyte aggregation.