RESUMEN
The influence of perspective anti-migraine drug tropoxin on the content of monoamines and related metabolites in Wistar rat brain structures, including frontal cortex (FC), hypothalamus, nucleus accumbens (NA), striatum, and hippocampus, has been studied using HPLC/ED technique. Tropoxin (10 mg/kg) induced a 30% decrease (p < 0.05) in dopamine (DA) level in FC as well as norepinephrine content in NA, while the concentrations of DA metabolites DOPAC and HVA in the hypothalamus were found to increase. The injection of tropoxin in a dose of 20 mg/kg led to an increase in HVA level in hypothalamus as well as seroto- nin metabolite 5-HIAA content in NA. The obtained data provide evidence that tropoxin predominantly influenced the activity of dopaminergic system while the drug effects on the parameters of serotoninergic link seem to be rather mild.
Asunto(s)
Compuestos Aza/farmacología , Compuestos Bicíclicos Heterocíclicos con Puentes/farmacología , Dopamina/metabolismo , Hipotálamo/metabolismo , Norepinefrina/metabolismo , Animales , Ratas , Ratas WistarRESUMEN
The effect of tropan on exocellular-recorded electrical activity of brain sensorimotor cortical and ventrolateral thalamic neurons was studied in acute experiments on rabbits. Tropan was injected intravenously in a dose of 1-5 mg/kg and applied microiontophoretically to individual neurons. With both routes of administration tropan increased the frequency of spontaneous activity of the majority of cortical and thalamic neurons in the dose-dependent form. The inhibitory action of the microiontophoretically applied catecholamines noradrenaline and dopamine on the activity of brain cortical neurons does not change under the effect of tropan. The stimulatory effect of catecholamines on ventrolateral thalamic neurons is potentiated by tropan. It is suggested that excitation of cortical and subcortical neurons, as well as potentiation of stimulatory catecholaminergic effects in the subcortex underlie the central stimulant effect of tropan.