Asunto(s)
Antiinfecciosos/administración & dosificación , Quemaduras por Inhalación/complicaciones , Quemaduras/complicaciones , Ciprofloxacina/administración & dosificación , Infección de Heridas/tratamiento farmacológico , Adolescente , Adulto , Anciano , Antiinfecciosos/efectos adversos , Quemaduras/microbiología , Quemaduras por Inhalación/microbiología , Ciprofloxacina/efectos adversos , Femenino , Humanos , Infusiones Intravenosas , Masculino , Persona de Mediana Edad , Inducción de Remisión , Factores de Tiempo , Infección de Heridas/microbiologíaRESUMEN
The efficacy of a home-made pefloxacin was estimated in clinico-laboratory trials including 25 patients with wound infection. The fluoroquinolone was used in a dose of 400 mg administered orally twice a day for 4-16 days. Good and satisfactory results were stated in 24 patients (96 per cent). The isolates from the patients were mainly susceptible to the drug (86.2 per cent). The bacteriological efficacy amounted to 92 per cent. No side effects to the use of pefloxacin were observed.
Asunto(s)
Antiinfecciosos/uso terapéutico , Quemaduras/complicaciones , Pefloxacina/uso terapéutico , Infección de Heridas/tratamiento farmacológico , Adolescente , Adulto , Anciano , Antiinfecciosos/farmacocinética , Quemaduras/metabolismo , Femenino , Humanos , Masculino , Pruebas de Sensibilidad Microbiana , Persona de Mediana Edad , Pefloxacina/efectos adversos , Pefloxacina/farmacocinética , Resultado del Tratamiento , Infección de Heridas/metabolismo , Infección de Heridas/microbiologíaRESUMEN
The efficacy of cefpirome was estimated in the treatment of 25 patients: 15 patients with pyo-necrotic wounds of the soft tissue of various genesis and localization and 10 patients with deep thermal burns involving 8 to 40 per cent of the body surface. The clinical and bacteriological efficacies of the treatment in the patients with the wound infection amounted to 100 and 80 per cent respectively. In the patients with the burn infection the respective values were 90 and 80 per cent. The drug tolerance was good. Adverse reactions were observed in 1 patient. Bolus intravenous administration of the drug was preferable by comparison with the injections.
Asunto(s)
Cefalosporinas/uso terapéutico , Enfermedades Cutáneas Bacterianas/tratamiento farmacológico , Infecciones de los Tejidos Blandos/tratamiento farmacológico , Infección de Heridas/tratamiento farmacológico , Adolescente , Adulto , Quemaduras/microbiología , Cefalosporinas/efectos adversos , Humanos , Pruebas de Sensibilidad Microbiana , Persona de Mediana Edad , Necrosis , Enfermedades Cutáneas Bacterianas/microbiología , Infecciones de los Tejidos Blandos/microbiología , Infecciones de los Tejidos Blandos/patología , Resultado del Tratamiento , Infección de Heridas/microbiología , CefpiromaRESUMEN
The experience with ofloxacin in the prophylaxis and treatment of infected burn wounds in 40 patients was investigated. High clinical and microbiological efficacy of the drug was stated (82.5 and 83 per cent respectively). The highest efficacy of ofloxacin was observed when the burned area did not exceed 25 per cent of the body surface. It was concluded that the prophylactic use of the drug during acute burn toxemia was not expedient.
Asunto(s)
Antiinfecciosos/uso terapéutico , Quemaduras/complicaciones , Ofloxacino/uso terapéutico , Toxemia/tratamiento farmacológico , Infección de Heridas/tratamiento farmacológico , Adulto , Anciano , Femenino , Humanos , Masculino , Pruebas de Sensibilidad Microbiana , Persona de Mediana Edad , Toxemia/microbiología , Toxemia/prevención & control , Resultado del Tratamiento , Infección de Heridas/microbiología , Infección de Heridas/prevención & controlRESUMEN
A clinical laboratory investigation of cefoperazon in the treatment of 27 patients with burn traumata and purulent necrotic wounds of the soft tissues of various genesis and localization was carried out. The clinical efficacy of the treatment was 75-86.6 per cent. 4 patients with extended purulent wounds of the soft tissues and bone affections were treated with cefoperazon and local application of gentacicol (a dosage form of gentamicin based on collagen with prolonged action) which provided the clinical effect in all the cases. 226 isolates from the wounds, urine, blood, sputum, pleural fluid and other substrates were tested and a rather high activity of cefoperazon against many strains of gram-positive and gram-negative organisms including Staphylococcus spp., Pseudomonas aeruginosa, Escherichia coli, Providencia sp. and Proteus spp. was revealed. The tolerance of the drug in all the cases was good.