RESUMEN
This article summarizes key aspects of progress made during 2004 toward the design, discovery and development of antiviral agents for clinical use. Important developments in the identification, characterization and clinical utility of inhibitors of human immunodeficiency virus; the hepatitis viruses, hepatitis B, hepatitis C; the herpes family of viruses, herpes simplex viruses 1 and 2, varicella zoster virus, Epstein-Barr virus and human cytomegalovirus; the respiratory viruses, influenza, respiratory syncytial virus, human metapneumovirus, picornaviruses, measles and the severe acute respiratory syndrome coronavirus; human papilloma virus; rotavirus; Ebola virus and West Nile virus, are reviewed.
Asunto(s)
Antivirales/química , Antivirales/farmacología , Diseño de Fármacos , VIH-1/efectos de los fármacos , VIH-2/efectos de los fármacos , Virus de Hepatitis/efectos de los fármacos , Herpesviridae/efectos de los fármacos , Secuencia de Aminoácidos , Animales , Fármacos Anti-VIH/química , Fármacos Anti-VIH/farmacología , Ensayos Clínicos como Asunto , Evaluación Preclínica de Medicamentos , Inhibidores de Integrasa VIH/química , Inhibidores de Integrasa VIH/farmacología , Humanos , Datos de Secuencia Molecular , Estructura Molecular , Inhibidores de la Síntesis del Ácido Nucleico , Nucleósidos/química , Nucleósidos/farmacología , Orthomyxoviridae/efectos de los fármacos , Inhibidores de Proteasas/química , Inhibidores de Proteasas/farmacología , Inhibidores de la Transcriptasa Inversa/química , Inhibidores de la Transcriptasa Inversa/farmacología , Coronavirus Relacionado al Síndrome Respiratorio Agudo Severo/efectos de los fármacosRESUMEN
The anti-influenza activity of a series of thiobenzamide fusion inhibitors derived from 1,3,3-trimethyl-5-hydroxy-cyclohexylmethylamine is profiled. Axial disposition of the thioamide moiety is essential for potent influenza inhibitory activity.