Retinal artery occlusion after ophthalmic surgery under regional anaesthesia: A narrative review.

Two recent cases of central retinal artery occlusion under otherwise uncomplicated sub-Tenon's block that resulted in significant visual loss after cataract surgery prompted us to undertake a literature review of such cases. We identified 97 cases of retinal artery occlusion after ophthalmic surgery under regional anaesthesia that had no immediate signs of block-related complications. These occurred after various intraocular (87%) and extraocular (13%) operations, across a wide range of ages (19-89 years) on patients with (59%) or without (39%) known risk factors. The anaesthetic techniques included 40 retrobulbar blocks, 36 peribulbar blocks, 19 sub-Tenon's blocks, one topical anaesthetic and one unspecified local anaesthetic. Different strengths of lidocaine, bupivacaine, mepivacaine and ropivacaine, either alone or in various combinations, were used. The details of the anaesthetic techniques were often incomplete in the reports, which made comparison and analysis difficult. Only nine cases had their cause (optic nerve sheath injury) identified, while the mechanism of injury was unclear in the remaining patients. Various mechanisms were postulated; however, the cause was likely to be multifactorial due to patient, surgical and anaesthetic risk factors, especially in those with compromised retinal circulation. As there were no definite risk factors identified, no specific recommendations could be made to avoid this devastating outcome. We have provided rationales for some general considerations, which may reduce this risk, and propose anaesthetic options for ophthalmic surgery on the fellow eye if required, based both on our literature review and our personal experience.

Anaesthetic considerations for the surgical management of ocular hypotony in adults.

Ocular hypotony can occur from many causes, including eye trauma, ophthalmic surgery and ophthalmic regional anaesthesia-related complications. Some of these patients require surgical intervention(s) necessitating repeat anaesthesia. While surgical management of these patients is well described in the literature, the anaesthetic management is seldom discussed. The hypotonous eye may also have altered globe anatomy, meaning that the usual ocular proprioceptive feedbacks during regional ophthalmic block may be altered or lost, leading to higher risk of inadvertent globe injury. In an 'open globe' there is a risk of sight-threatening expulsive choroidal haemorrhage as a consequence of ophthalmic block or general anaesthesia. This narrative review describes the physiology of aqueous humour, the risk factors associated with ophthalmic regional anaesthesia-related ocular hypotony, the surgical management, and a special emphasis on anaesthetic management. Traumatic hypotony usually requires urgent surgical repair, whereas iatrogenic hypotony may be less urgent, with many cases scheduled as elective procedures. There is no universal best anaesthetic technique. Topical anaesthesia and regional ophthalmic block, with some technique modifications, are suitable in many mild-to-moderate cases, whilst general anaesthesia may be required for complex and longer procedures, and severely distorted globes.

Sub-Tenon's anaesthesia for modern eye surgery-clinicians' perspective, 30 years after re-introduction.

Sub-Tenon's block (STB) is a good technique of local anaesthesia for many types of eye surgery. It has a relatively good risk profile, in that sight- and life-threatening complications appear to be extremely rare. STB has gained popularity in the last three decades, with refinements including different types of blunt metal cannula, plastic cannulae and 'incisionless' approaches. Usage of STB varies significantly across the globe. This narrative review documents the historical evolution of STB techniques, anatomical and physiological considerations, its utility and suitability, complications, explores the current practice and possible future applications.

Comparative study of silicone membrane simulator and animal eye models for sub-Tenon's block.

To compare and assess silicone membrane-based sub-Tenon's block (STB) simulator and animal eye model (goat's eye) for practicing STB in terms of anatomical similarity and feel of texture of eye layers. The study included 34 participants (26 learners and 8 consultants) from tertiary ophthalmic centres. The participants were divided into groups A and B. Group A performed STB on the goat's eyes before using the silicone membrane simulator. Group B performed STB on the simulator and further proceeded to the goat's eye. Participants had to rate the anatomical similarity and feel of the texture for the simulator model on a scale of 0-10 and share their preference between the two models. In group A, the scores given to the simulator model and the feel of texture of layers were 8.05 ± 0.88 and 7.97 ± 1.07, respectively, and the scores given to the animal model and the feel of texture of layers were 8.11 ± 0.97 and 8.21 ± 0.88, respectively. Group B participants scored the simulator model and feel of texture of layers with 8.13 ± 0.95 and 8.25 ± 0.99, respectively. Overall, 89% participants preferred the simulator; the reasons included ease of usage, helpful warning system, absence of biological waste, and facility for repeatable training. The study validated anatomical accuracy, preference, and ability of usage of the STB simulator. For broader usage, further study involving higher number of participants is recommended.

Lacrimal dilator-facilitated incisionless vs. standard sub-Tenon's block: a randomized, prospective and non-inferiority comparative study.

BACKGROUND/OBJECTIVES: Standard sub-Tenon's block (STB) involves incision (dissection) of conjunctiva and Tenon's capsule with the help of blunt scissors and forceps, insertion of a blunt sub-Tenon's cannula under the Tenon's capsule and injection of local anaesthetic agent. STB is frequently associated with minor complications such as chemosis and postoperative subconjunctival haemorrhage but rare sight and life-threatening complications. To reduce these minor complications, several variations of incisionless STB have been described however, there are no comparative data. One such incisionless STB involves the use of lacrimal dilator which is easily available in the operating theatre. We compared incisionless lacrimal dilator-facilitated with the standard STB for effectiveness, chemosis, and postoperative subconjunctival haemorrhage. SUBJECTS/METHODS: After obtaining ethical approval, patients scheduled to undergo elective phacoemulsification cataract surgery were enroled to receive incisionless lacrimal dilator-facilitated STB (Group LD) or a standard STB using Wescott scissors and blunt forceps (Group WS). All patients received 3 mL 2% lidocaine without any adjuvant. No sedation was administered. Demographics of the patients, duration of the procedure, analgesia, akinesia, duration of the procedure intraoperative chemosis, and postoperative subconjunctival haemorrhage were compared. RESULTS: Both groups were comparable for demographic data, duration of the procedure, analgesia, and akinesia (p > 0.05). The severity of chemosis and postoperative subconjunctival haemorrhage were significantly lower in Group LD (n = 32) in comparison to Group WS (n = 31) (p < 0.001). CONCLUSIONS: Incisionless lacrimal dilator-facilitated STB decreases intraoperative chemosis and postoperative conjunctival haemorrhage in comparison to standard STB. Analgesia and akinesia are comparable in both techniques.

Effect of sedation on visual sensations in patients undergoing cataract surgery under topical anaesthesia: a prospective randomized masked trial.

PURPOSE: The main aim of the study was to determine whether intravenous sedation with midazolam reduces the ability of patients to see during cataract surgery performed under topical anaesthesia. We also sought to determine the effects of sedation on patient's level of disturbance to the microscope light and visualization of surgical instruments and on the overall of experience of the patients during surgery. METHODS: A total of 78 patients, aged 40-75 years, were randomly divided into two groups: Group S, (sedation) who received intravenous midazolam 0.015 mg/kg, and Group NS, (no sedation) who did not receive midazolam. Patients with history of anxiety, those with history of intraocular surgery and those with severe chronic obstructive pulmonary disease were excluded. Topical anaesthesia was achieved by the application of 2% xylocaine gel over the conjunctiva. A blinded observer interviewed all the patients 30 min after the surgery using a standard questionnaire. RESULTS: Significant number of patients (25.6%) in Group NS was disturbed a lot because of the microscope light compared to Group S (5.1%), p = 0.021. Also, statistically significant number of patients in Group S (48.7%) compared to Group NS (20.5%) was not sure about the images perceived during surgery and were unable to recollect them after the surgery, p = 0.008, and 12.8% of the patients in Group NS reported the visual experience as frightening compared to 2.6% of patients in Group S, p = 0.239. CONCLUSION: Our study confirms that intravenous midazolam reduces both the ability to see and recall intraoperative visual images in patients undergoing cataract surgery under topical anaesthesia.

Comparison of metal and flexible sub-Tenon cannulas.

PURPOSE: To compare metal posterior, flexible posterior, and flexible medium sub-Tenon cannulas for akinesia and anesthesia. SETTING: King Khaled Specialist Eye Hospital, Riyadh, Saudi Arabia. DESIGN: Prospective blind randomized comparison. METHOD: Patients having cataract surgery under sub-Tenon block received a mixture of bupivacaine and lidocaine with hyaluronidase. The patients were divided into 3 groups based on whether a metal posterior sub-Tenon cannula, flexible posterior sub-Tenon cannula, or flexible medium sub-Tenon cannula was used. Pain during injection, akinesia, anesthesia, and complications were recorded. RESULTS: The study enrolled 159 patients. The akinesia score, superior oblique muscle activity, lid movements, and pain during injection were significantly lower in the metal posterior cannula group 2 minutes after injection (P=.002, P=.008, P=.097, and P=.001, respectively); there was no significant difference at 4 minutes, 6 minutes, 8 minutes, and 10 minutes. The incidence of intraoperative pain was low in all groups (P=.607). Chemosis was significantly less in the flexible posterior cannula group (P=.003); however, there was no significant difference in the site of chemosis (P=.460). There was no significant difference in the incidence, site, or severity of subconjunctival hemorrhage (P=.087, P=.072, and P=.331, respectively). No serious complications occurred. CONCLUSIONS: Rigid posterior, flexible posterior, and flexible medium cannulas produced effective and equivalent anesthesia. The flexible cannulas may be safer than the rigid cannulas. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.

What can patients see during glaucoma filtration surgery under peribulbar anesthesia?

PURPOSE: To describe the visual sensations experienced by patients during glaucoma filtration surgery under peribulbar anesthesia and to determine possible risk factors that may affect the visual sensations experienced. SETTING: King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia. METHODS: In this prospective questionnaire study, 75 consecutive adult patients listed for glaucoma filtration surgery (trabeculectomy or Ahmed tube implantation) under peribulbar anesthesia were interviewed postoperatively about the visual sensations experienced in their operated eye during the surgery. RESULTS: The mean age of the 75 patients was 59.7 years (range, 27 to 83, SD +/-12.1). Sixty-five patients (86.7%) perceived light perception during the surgery and the overall light intensity fluctuated in 45 patients (60.0%). The mean age of the patients who retained light perception intraoperatively was significantly lower compared with those who lost light perception (58.3 y vs. 68.8 y; P=0.009). Forty-six patients (61.3%) were able to perceive colors, 32 patients (42.7%) perceived movement, 31 patients (41.3%) saw surgical instruments, and 33 patients (44.0%) reported seeing the surgeon's hands or fingers. The severity of glaucoma did not affect the proportion of patients who perceived the various visual sensations. One patient (1.3%) was frightened by his intraoperative visual experience. Of the remaining patients, 53 (70.7%) said the visual sensations did not affect them, whereas 21 (28.0%) found them unpleasant. CONCLUSIONS: The majority of patients undergoing glaucoma filtration surgery retained light perception intraoperatively and many also experienced various visual sensations. Only 1.3% of patients were frightened by their visual experience.

Sub-Tenon's Anesthesia.

The sub-Tenon's anesthesia block was reintroduced into clinical practice in the early 1990s as a simple, effective, and safe alternative to needle blocks. The technique has remained simple and effective but has evolved. Although still very unusual, both sight- and life-threatening complications have occurred. To safely perform the block, detailed knowledge of anatomy and methods for administering anesthesia are essential.

Visual experiences during cataract surgery: what anaesthesia providers should know.

Recently published literature shows that most patients experience a variety of visual sensations during cataract surgery under local anaesthesia. Most patients (80-100%) retain at least some light perception in the operated eye and many also experience a variety of other visual sensations during cataract surgery under regional ophthalmic anaesthesia (retrobulbar, peribulbar and sub-Tenon's blocks) or topical anaesthesia. The visual sensations experienced include perception of movements, flashes, colours, changes in brightness, or the sight of surgical instruments, the surgeon's hands or fingers, or even the surgeon. These findings are clinically significant because 3-16.2% of patients who had cataract surgery under either regional or topical anaesthesia were frightened by their intraoperative visual experience. Fear and anxiety may cause some patients to become uncooperative during the surgery and may also induce a sympathetic stress response that might cause hypertension, tachycardia with myocardial ischaemia, hyperventilation or an acute panic attack. These effects are especially undesirable as the majority of cataract patients are elderly and have concurrent medical problems. Besides increasing the risk of intraoperative complications, a frightening visual experience may decrease patient satisfaction. Appropriate preoperative counselling has been shown to be effective in reducing the patients' fear. As most patients retain some visual function during cataract surgery under local anaesthesia, anaesthesia providers should be mindful of this phenomenon and offer appropriate preoperative information and counselling to their patients.

Sub-Tenon's block with an ultrashort cannula.

PURPOSE: To evaluate the effectiveness and safety of an orbital block using an ultrashort, wide-bore blunt metal cannula to inject local anesthetic agents into the anterior sub-Tenon's space. SETTING: Department of Ophthalmology, North Riding Infirmary, Middlesbrough, United Kingdom. METHODS: Fifty-nine consecutive patients having routine phacoemulsification with intraocular lens implantation were studied. Five milliliters of lidocaine 2% with adrenaline 1:200000 and hyaluronidase 150 units was injected into the anterior sub-Tenon's space in the inferonasal quadrant via a 16-gauge, short (0.6 cm), blunt metal cannula. Horizontal and vertical movements were assessed before injection and 2, 4, and 6 minutes after injection (also at 8 and 10 minutes if akinesia was inadequate). The movements were scored from 0 (no movement) to 3 (full movement). Incyclotorsion and lid movements were assessed at the same intervals. In the first 15 patients, B-scan ultrasonography was performed before, during, and 2 minutes after the injection. If the aggregate akinesia score was higher than 4 at 6 minutes, a supplementary injection was given. Pain during the injection and surgery was assessed using a 10-point verbal rating score. The incidence, severity, and quadrant of chemosis and conjunctival hemorrhage were noted. RESULTS: Forty-eight patients (81.35%) had an aggregate akinesia score lower than 4 at 2 minutes and 58 (98.30%) at 4 minutes. One patient had an akinesia score higher than 4 at 6 minutes and required supplementary injection. Incyclotorsion was present in 42 patients (72.88%) at 2 minutes and in 19 (32.20%) at 4 minutes. Lid opening (levator function) was present in 33 patients (55.93%) at 2 minutes and in 19 (32.20%) at 4 minutes. Lid closure (orbicularis function) was present in 34 patients (57.62%) at 2 minutes and in 18 (30.50%) at 4 minutes. One patient required a supplementary injection at 10 minutes. Ultrasonography showed the injection caused rapid opening of sub-Tenon's space, with fluid spreading around the optic nerve. No pain on injection occurred in 67.79% of patients; 17 (28.81%) had a verbal rating score of 1, 1 (1.69%) had a score of 3, and 1 had a score of 5. No patient reported pain during surgery. A minor degree of chemosis and conjunctival hemorrhage occurred in 43 patients and 37 patients, respectively. Moderate chemosis occurred in 15 cases and severe chemosis in 1 case. CONCLUSIONS: Effective and predictable ocular anesthesia can be achieved using a blunt, ultrashort cannula for sub-Tenon's block. The technique greatly reduces the risks for globe perforation, muscle damage, and other serious complications.