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1.
In Vivo ; 24(5): 735-43, 2010.
Artículo en Inglés | MEDLINE | ID: mdl-20952742

RESUMEN

Previous studies have shown anti-inflammatory potential of alkaline extract of the leaves of Sasa senanensis Rehder (SE). The aim of the present study was to clarity the molecular entity of SE, using various fractionation methods. SE inhibited the production of nitric oxide (NO), but not tumour necrosis factor-α by lipopolysaccharide (LPS)-stimulated mouse macrophage-like cells. Lignin carbohydrate complex prepared from SE inhibited the NO production to a comparable extent with SE, whereas chlorophyllin was more active. On successive extraction with organic solvents, nearly 90% of SE components, including chlorophyllin, were recovered from the aqueous layer. Anti-HIV activity of SE was comparable with that of lignin-carbohydrate complex, and much higher than that of chlorophyllin and n-butanol extract fractions. The CYP3A inhibitory activity of SE was significantly lower than that of grapefruit juice and chlorophyllin. Oral administration of SE slightly reduced the number of oral bacteria. When SE was applied to HPLC, nearly 70% of SE components were eluted as a single peak. These data suggest that multiple components of SE may be associated with each other in the native state or after extraction with alkaline solution.


Asunto(s)
Álcalis/administración & dosificación , Antiinflamatorios/administración & dosificación , Macrófagos/efectos de los fármacos , Extractos Vegetales/administración & dosificación , Sasa/química , Estomatitis/tratamiento farmacológico , Animales , Infecciones por Bacteroidaceae/tratamiento farmacológico , Infecciones por Bacteroidaceae/inmunología , Infecciones por Bacteroidaceae/microbiología , Línea Celular , Clorofilidas/farmacología , Citrus paradisi/química , Infecciones por VIH/tratamiento farmacológico , Humanos , Lignina/farmacología , Lipopolisacáridos/farmacología , Macrófagos/citología , Macrófagos/metabolismo , Masculino , Ratones , Microsomas Hepáticos/efectos de los fármacos , Óxido Nítrico/metabolismo , Porphyromonas gingivalis/efectos de los fármacos , Porphyromonas gingivalis/crecimiento & desarrollo , Ratas , Estomatitis/inmunología , Estomatitis/microbiología , Factor de Necrosis Tumoral alfa/metabolismo
2.
In Vivo ; 22(4): 471-6, 2008.
Artículo en Inglés | MEDLINE | ID: mdl-18712174

RESUMEN

Sasa senanensis Rehder extract (SE) showed slightly higher cytotoxicity against human squamous cell carcinoma cell lines and human glioblastoma cell lines, as compared with human oral normal cells (gingival fibroblast, pulp cell, periodontal ligament fibroblast), and was more cytotoxic to human myelogenous and T-cell leukemia cell lines. SE showed a bacteriostatic effect on Fusobacterium nucleatum and Prevotella intermedia, but almost completely eliminated hydrogen sulfide (H2S) and methyl mercaptan (CH3SH) produced by these bacteria. SE protected human T-cell leukemia MT-4 cells from the cytopathic effect of human immunodeficiency virus (HIV) infection, and its anti-HIV activity was much higher than that of tannins and flavonoids, comparable with that of natural and synthetic lignins. SE also protected the MDCK cells from the cytopathic effect of influenza virus infection. SE synergistically enhanced the superoxide anion and hydroxyl radical-scavenging activity of vitamin C. The present study suggests the functionality of SE as a complementary alternative medicine.


Asunto(s)
Antibacterianos/farmacología , Antivirales/farmacología , Ácido Ascórbico/metabolismo , Ácido Ascórbico/farmacología , Extractos Vegetales/farmacología , Sasa/metabolismo , Animales , Fármacos Anti-VIH/farmacología , Línea Celular , Línea Celular Tumoral , Perros , Sinergismo Farmacológico , Fibroblastos/metabolismo , Depuradores de Radicales Libres/farmacología , Infecciones por VIH/prevención & control , Humanos
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