Dermaceutical Utilization of Nigella sativa Seeds: Applications and Opportunities.

Skin diseases have recently become a major concern among people of all ages due to their highly visible symptoms and persistent and difficult treatment, which significantly impact their quality of life. Nigella sativa seeds, also known as "black seeds" or "kalonji," are one of the most commonly used herbal medicines due to their wide range of biological and pharmacological activities. It contains a wide range of bioactive constituents found in both fixed and essential oils. It has been used for hundreds of years as an alternative ethnomedicine to treat a wide range of skin conditions. N. sativa's dermatological applications in skin diseases are attributed to its potent antioxidant, anti-inflammatory, antimicrobial, and immunomodulatory properties, making it an intriguing skincare candidate. Several studies unravelled positive results associated with N. sativa on skin diseases. As N. sativa is the most studied medicinal plant, several preclinical and clinical studies have been conducted to establish its use in the treatment of various skin diseases. Thymoquinone has anti-inflammatory, antioxidant, and antibacterial properties, which mainly contributed to the treatment of skin diseases. In this context, the present review explores all the available studies on the association of N. sativa and its effect on treating skin diseases in light of recent studies and patents supporting its therapeutic applications.

Recent Trends in Biologically Synthesized Metal Nanoparticles and their Biomedical Applications: a Review.

In recent years, biologically synthesized metal nanoparticles have emerged as a dynamic field of research with significant implications for biomedical applications. This review explores the latest trends in the synthesis of metal nanoparticles using biological methods, encompassing plant extracts and microorganisms such as bacteria, yeasts, and fungi. These innovative approaches offer a sustainable, cost-effective, and environmentally friendly alternative to conventional chemical synthesis methods. Moreover, this review delves into the multifaceted biomedical applications of biologically synthesized metal nanoparticles. These applications include drug delivery systems, diagnostics, therapeutics, and imaging technologies, showcasing the versatility and promise of these nanomaterials in addressing contemporary biomedical challenges. In addition, the review addresses the critical issue of cytotoxicity, offering insights into the safety and viability of these biologically derived NPs for medical use. The exploration of recent trends and advancements in this field underscores the transformative potential of biologically synthesized metal nanoparticles in revolutionizing biomedical research and healthcare.

Exploring the Potential of Traditional Herbs in the Management of Diabetic Retinopathy: An Overview.

Diabetic retinopathy is a microvascular complication in diabetes that affects eyes and is responsible for most visual impairment in diabetic patients. Diabetic retinopathy affects up to 80% of those who have had diabetes for 20 years or more. At least 90% of new cases could be reduced with proper treatment and monitoring of the eyes. The longer a person has diabetes, the higher his or her chances of developing diabetic retinopathy. Hence, it compels need for its prevention and cure. There is an increasing interest in natural products in pharmacotherapy as the chemical diversity of natural products has better matches than the diversity of synthetic compounds. The current review summarises the potential of leading traditional herbs like Azadirachta indica, Ginkgo biloba, Anisodus tanguticus, Pinus pinaster, Salvia miltiorrhiza, Stephania tetrandra and Gymnema sylvestre in the management and potential reversal of DR-related pathogenesis. It also discusses the probable mechanism of actions, which are based on epidemiological, in-vitro and in-vivo studies carried out within past few years. Graphical Abstract.