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Nanomedicine (Lond) ; 13(17): 2171-2185, 2018 09.
Artículo en Inglés | MEDLINE | ID: mdl-30277422

RESUMEN

AIM: Sol-gel is a suitable and advantageous method to synthesize mixed oxide nanomaterials with unique physicochemical and biological properties. MATERIALS & METHODS: In this work, TiO2-SiO2 nanopowders cogeled with platinum acetylacetonate were developed and studied in the perspective of nanomedicine. The physicochemical properties of the Pt/TiO2-SiO2 nanopowders, named NanoRa2-Pt, were evaluated in detail by means of complementary spectroscopic and microscopic tools. The nanopowder's biocatalytic efficiency in wound healing was evaluated in a Type I diabetes animal model. RESULTS: These are TiO2-SiO2 submicron mesoporous particles with variable size and shape containing ultra-small platinum nanoparticles with catalytic properties. CONCLUSION: The use of NanoRa2-Pt catalyzes the natural healing processes with a faster remodeling stage. These sols, which we call nanobiocatalysts, belong to an emerging and very promising research field known as catalytic nanomedicine.


Asunto(s)
Nanopartículas/química , Platino (Metal)/química , Dióxido de Silicio/química , Titanio/química , Cicatrización de Heridas/efectos de los fármacos , Animales , Catálisis , Complicaciones de la Diabetes/tratamiento farmacológico , Complicaciones de la Diabetes/fisiopatología , Diabetes Mellitus Tipo 1/complicaciones , Diabetes Mellitus Tipo 1/tratamiento farmacológico , Humanos , Masculino , Nanopartículas del Metal/química , Nanomedicina , Porosidad , Ratas , Ratas Wistar , Propiedades de Superficie
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