RESUMEN
An extract from in vitro cultures of Curculigo orchioides grown as bulbils in shake flasks, afforded two new glucosides of substituted benzylbenzoate - curculigoside C (3) and curculigoside D (4) - together with two known compounds - curculigoside A (1) and curculigoside B (2). Their structures were elucidated on the basis of spectral evidence, in particular by using 2D NMR methods. Their vasoactive properties were assessed in isolated rat aortic rings.
Asunto(s)
Curculigo , Fitoterapia , Extractos Vegetales/farmacología , Vasoconstricción/efectos de los fármacos , Vasoconstrictores/farmacología , Animales , Aorta/efectos de los fármacos , Compuestos de Bencilo/administración & dosificación , Compuestos de Bencilo/química , Compuestos de Bencilo/farmacología , Compuestos de Bencilo/uso terapéutico , Relación Dosis-Respuesta a Droga , Endotelio Vascular/efectos de los fármacos , Glucósidos/administración & dosificación , Glucósidos/química , Glucósidos/farmacología , Glucósidos/uso terapéutico , Espectroscopía de Resonancia Magnética , Masculino , Extractos Vegetales/administración & dosificación , Extractos Vegetales/química , Extractos Vegetales/uso terapéutico , Hojas de la Planta , Ratas , Ratas Wistar , Vasoconstrictores/administración & dosificación , Vasoconstrictores/química , Vasoconstrictores/uso terapéuticoRESUMEN
Three new monomeric stilbenoid glucosides, (Z)- and (E)-resveratrol 3,5- O-beta-diglucosides (1 and 2, respectively) and (Z)-resveratrol 3,5,4'- O-beta-triglucoside (3), were isolated from an extract of Vitis vinifera cell cultures (Cabernet Sauvignon) together with the known (E)- and (Z)-piceids and (E)- and (Z)-resveratrol 3,4'- O-beta-diglucosides that have already been identified in a Gamay cell culture extract. The structure determinations were based on spectroscopic data analysis.