RESUMEN
One new sesquiterpenoid, namely coprinol (1), along with guanacastanes J (2), E (3) and N (4), were isolated from the ethyl acetate extracts of the fermented broths of the fungal strain Coprinellus radians ≠1168. Their structures were elucidated on the basis of spectroscopic data analysis. The growth inhibitory activities against A549 of 1-4 were evaluated, and only 4 exhibited moderate growth inhibitory activity with a GI50 value of 18.2 µM compared with fluorouracil (GI50 = 3.6 µM). All the compounds were also subjected to antifungal assay against Candida albicans ATCC 18804, C. albicans SC-5314, Cryptococcus neoformans ATCC 13690 and Saccharomyces cerevisiae ATCC 2345; all showed mild antifungal activity with MIC values of 128.0 µg/mL for 1-3 and 64.0 µg/mL for 4 in comparison with amphotericin B (MIC = 0.25 µg/mL) and ketoconazole (MIC = 1.0 µg/mL).
Asunto(s)
Agaricales/química , Antifúngicos/farmacología , Terpenos/aislamiento & purificación , Antifúngicos/aislamiento & purificación , Candida albicans/efectos de los fármacos , Cryptococcus neoformans/efectos de los fármacos , Fermentación , Estructura Molecular , Saccharomyces cerevisiae/efectos de los fármacos , Taiwán , Terpenos/farmacologíaRESUMEN
One new γ-lactone, namely calolactone (1), together with one new drimane-type sesquiterpene, namely caloterpene (2), were isolated from the pericarp of Calocedrus formosana Florin. Their structures were elucidated by spectroscopic and mass spectrometric analysis.