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Neurotoxicol Teratol ; 19(1): 59-63, 1997.
Artículo en Inglés | MEDLINE | ID: mdl-9088011

RESUMEN

Aluminum (Al) has been proven to be a behavioral teratogenic agent in a number of experimental studies. Prenatal exposures to Al lactate have been shown to cause cognitive deficits in a variety of species. The present experiment was carried out on SPRD rat pups treated prenatally with Al lactate to determine whether observational conditioning (social learning) would reverse the impairment in learning described previously following such treatment. A conditioned avoidance response was used as an observational learning task. The results provide evidence that Al-treated pups are capable of social learning (i.e., the performance of the avoidance response improved as a result that Al-treated learning); however, the response latency of the avoidance response was not different in these animals from those that were not exposed to such facilitation, suggesting that additional factors are involved in the effects of prenatal aluminum intoxication on cognitive processes.


Asunto(s)
Compuestos de Aluminio/toxicidad , Reacción de Prevención/efectos de los fármacos , Condicionamiento Operante/efectos de los fármacos , Lactatos/toxicidad , Efectos Tardíos de la Exposición Prenatal , Conducta Social , Teratógenos/toxicidad , Análisis de Varianza , Animales , Evaluación Preclínica de Medicamentos , Femenino , Masculino , Embarazo , Ratas
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