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Métodos Terapéuticos y Terapias MTCI
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1.
Physiol Res ; 68(5): 835-844, 2019 10 25.
Artículo en Inglés | MEDLINE | ID: mdl-31424247

RESUMEN

Opiate addiction has a high rate of relapse. The accumulating evidence shows that electroacupuncture (EA) may be effective for the treatment of opiate relapse. However, the change of expression of CB1-Rs and CB2-Rs involve in 2Hz EA anti-relapse pathway is still unclear. To explore the changes of expression of CB1-Rs and CB2-Rs, heroin self-administration (SA) model rats were adopted and treated using 2Hz EA. The expressions of CB1-Rs and CB2-Rs were observed using immunohistochemistry method. The results showed that, compared with the control group, active pokes in the heroin-addicted group increased, while the active pokes decreased significantly in 2Hz EA group compared with heroin-addicted group. Correspondingly, the expression of CB1-Rs in prefrontal cortex (PFC), hippocampus (Hip), nucleus accumbens (NAc) and ventral tegmental area (VTA) all increased significantly while the expression of CB2-Rs in those relapse-relevant brain regions decreased obviously in heroin-addicted group when compared with the control group. In addition, the expression of CB1-Rs obviously decreased in the 2Hz EA group while the expression of CB2-Rs in those relapse-relevant brain regions increased significantly when compared with the heroin-addicted group. It indicated that 2Hz EA could attenuate the heroin-evoked seeking behaviors effectively. The anti-relapse effects of 2Hz EA might be related to the decrease of CB1-Rs and increase of CB2-Rs expression in relapse-relevant brain regions of heroin SA rats.


Asunto(s)
Conducta Animal/efectos de los fármacos , Encéfalo/efectos de los fármacos , Comportamiento de Búsqueda de Drogas/efectos de los fármacos , Electroacupuntura , Dependencia de Heroína/terapia , Heroína/administración & dosificación , Antagonistas de Narcóticos/administración & dosificación , Receptor Cannabinoide CB1/metabolismo , Receptor Cannabinoide CB2/metabolismo , Animales , Encéfalo/metabolismo , Encéfalo/fisiopatología , Modelos Animales de Enfermedad , Extinción Psicológica/efectos de los fármacos , Dependencia de Heroína/metabolismo , Dependencia de Heroína/fisiopatología , Dependencia de Heroína/psicología , Locomoción/efectos de los fármacos , Masculino , Ratas Sprague-Dawley , Recurrencia , Autoadministración , Transducción de Señal
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