RESUMEN
Olfaction plays an important role in emotions in our daily life. Pleasant odors are known to evoke positive emotions, inducing relaxation and calmness. The beneficial effects of vanillin on depressive model rats were investigated using a combination of behavioral assessments and neurotransmitter measurements. Before and after chronic stress condition (or olfactory bulbectomy), and at the end of vanillin or fluoxetine treatment, body weight, immobility time on the forced swimming test and sucrose consumption in the sucrose consumption test were measured. Changes in these assessments revealed the characteristic phenotypes of depression in rats. Neurotransmitters were measured using ultrahigh-performance liquid chromatography. Our results indicated that vanillin could alleviate depressive symptoms in the rat model of chronic depression via the olfactory pathway. Preliminary analysis of the monoamine neurotransmitters revealed that vanillin elevated both serotonin and dopamine levels in brain tissue. These results provide important mechanistic insights into the protective effect of vanillin against chronic depressive disorder via olfactory pathway. This suggests that vanillin may be a potential pharmacological agent for the treatment of major depressive disorder.
Asunto(s)
Aromaterapia , Benzaldehídos/farmacología , Depresión/fisiopatología , Depresión/psicología , Dopamina/metabolismo , Bulbo Olfatorio/efectos de los fármacos , Bulbo Olfatorio/fisiopatología , Serotonina/metabolismo , Olfato/efectos de los fármacos , Olfato/fisiología , Animales , Nivel de Alerta/efectos de los fármacos , Nivel de Alerta/fisiología , Trastorno Depresivo Mayor/fisiopatología , Trastorno Depresivo Mayor/psicología , Modelos Animales de Enfermedad , Emociones/efectos de los fármacos , Emociones/fisiología , Masculino , Vías Olfatorias/efectos de los fármacos , Vías Olfatorias/fisiopatología , Ratas , Ratas Sprague-Dawley , Privación Sensorial/fisiologíaRESUMEN
OBJECTIVE: To research the protective effect of pueraria flavonoid on the cerebral ischemic reperfusion injury. METHOD: Using the middle cerebral artery occlusion model (MCAO) in rats, we investigated the influence of pueraria flavonoid on the brain water content, the infarct volume, the activities of SOD, and the content of MDA. RESULT: Pueraria Flavonoid could obviously reduce the brain water content and the infract volume in MCAO, increase the activities of SOD, and decrease the content of MDA in the cerebral ischemia- reinfusion model of rats. CONCLUSION: Pueraria has the function of scavenging free radicals and the protective effect on ischemic brain tissue.
Asunto(s)
Encéfalo/patología , Flavonoides/farmacología , Fármacos Neuroprotectores/farmacología , Pueraria , Daño por Reperfusión , Animales , Encéfalo/metabolismo , Femenino , Flavonoides/aislamiento & purificación , Infarto de la Arteria Cerebral Media/complicaciones , Masculino , Malondialdehído/metabolismo , Fármacos Neuroprotectores/aislamiento & purificación , Plantas Medicinales/química , Pueraria/química , Distribución Aleatoria , Ratas , Ratas Sprague-Dawley , Daño por Reperfusión/etiología , Daño por Reperfusión/metabolismo , Daño por Reperfusión/patología , Superóxido Dismutasa/metabolismoRESUMEN
These active components and monomes inhibit thrombosis aimed directly at activation, adhesiveness and aggregation of platelet, thus preventing and curing ischemic cardiovascular and cerebrovascular diseases. Here we summarized the effect of active components and monomes of the traditional Chinese medicine targeted platelet on ischemic cardiovascular and cerebrovascular diseases, to provide references for drug investigation and clinical application.