3D Knee and Hip Angle Estimation With Reduced Wearable IMUs via Transfer Learning During Yoga, Golf, Swimming, Badminton, and Dance.

Wearable lower-limb joint angle estimation using a reduced inertial measurement unit (IMU) sensor set could enable quick, economical sports injury risk assessment and motion capture; however the vast majority of existing research requires a full IMU set attached to every related body segment and is implemented in only a single movement, typically walking. We thus implemented 3-dimensional knee and hip angle estimation with a reduced IMU sensor set during yoga, golf, swimming (simulated lower body swimming in a seated posture), badminton, and dance movements. Additionally, current deep-learning models undergo an accuracy drop when tested with new and unseen activities, which necessitates collecting large amounts of data for the new activity. However, collecting large datasets for every new activity is time-consuming and expensive. Thus, a transfer learning (TL) approach with long short-term memory neural networks was proposed to enhance the model's generalization ability towards new activities while minimizing the need for a large new-activity dataset. This approach could transfer the generic knowledge acquired from training the model in the source-activity domain to the target-activity domain. The maximum improvement in estimation accuracy (RMSE) achieved by TL is 23.6 degrees for knee flexion/extension and 22.2 degrees for hip flexion/extension compared to without TL. These results extend the application of motion capture with reduced sensor configurations to a broader range of activities relevant to injury prevention and sports training. Moreover, they enhance the capacity of data-driven models in scenarios where acquiring a substantial amount of training data is challenging.

A Traditional Chinese Medicine Xiao-Ai-Tong Suppresses Pain through Modulation of Cytokines and Prevents Adverse Reactions of Morphine Treatment in Bone Cancer Pain Patients.

Treating cancer pain continues to possess a major challenge. Here, we report that a traditional Chinese medicine Xiao-Ai-Tong (XAT) can effectively suppress pain and adverse reactions following morphine treatment in patients with bone cancer pain. Visual Analogue Scale (VAS) and Quality of Life Questionnaire (EORTC QLQ-C30) were used for patient's self-evaluation of pain intensity and evaluating changes of adverse reactions including constipation, nausea, fatigue, and anorexia, respectively, before and after treatment prescriptions. The clinical trials showed that repetitive oral administration of XAT (200 mL, bid, for 7 consecutive days) alone greatly reduced cancer pain. Repetitive treatment with a combination of XAT and morphine (20 mg and 30 mg, resp.) produced significant synergistic analgesic effects. Meanwhile, XAT greatly reduced the adverse reactions associated with cancer and/or morphine treatment. In addition, XAT treatment significantly reduced the proinflammatory cytokines interleukin-1ß and tumor necrosis factor-α and increased the endogenous anti-inflammatory cytokine interleukin-10 in blood. These findings demonstrate that XAT can effectively reduce bone cancer pain probably mediated by the cytokine mechanisms, facilitate analgesic effect of morphine, and prevent or reduce the associated adverse reactions, supporting a use of XAT, alone or with morphine, in treating bone cancer pain in clinic.

[Progress on pain control during the perioperative period of shoulder arthroscopy].

Successful pain management of perioperative shoulder arthroscopy may allow patients to go home earlier, improve the quality of life in perioperative period, and facilitate rehabilitation. A comprehensive method to perioperative pain control has three stages including preoperative, intraoperative and postoperative phase. Successful pain reduction should begin preoperatively because of an excellent communication between patient and physician, moreover, preoperative analgesia also should be administered. Intraoperative efforts should include local wound infiltration and the administration of anesthetic medication intra-articularly. Postoperative management should include oral analgesics, constant infusion devices, Patient Controlled Analgesia (PCA), sedative-hypnotic drug, continuous cryotherapy and vicarious treatment.