RESUMEN
BACKGROUND AND AIMS: Suboptimal health and metabolic disorders are common in the general population. Both are related to cardiovascular disease. Suboptimal cardiovascular health is defined by the presence of both suboptimal health and metabolic disorders. The aim of the study was to investigate the potential benefit of n-3 long-chain polyunsaturated fatty acids (LCPUFA) in participants with suboptimal cardiovascular health. METHODS AND RESULTS: A total of 422 participants with suboptimal cardiovascular health, from two clinics in China, were enrolled from September 2014 to April 2015. All the enrolled participants were randomly assigned to receive 4 g/d of fish oil or placebo for three months. Suboptimal health was defined using an accepted questionnaire. Metabolic disorders were defined as one or more abnormalities in blood pressure, fasting plasma glucose, blood lipids, and body mass index (BMI). After treatment, the mean BMI fell significantly more in the n-3 LCPUFA group than in the placebo group (-0.29 ± 0.06 kg/m2 vs. -0.02 ± 0.06 kg/m2, P = 0.003). Similar results were found in the changes of suboptimal health status and suboptimal cardiovascular health status (P < 0.05 for all). In a multivariate analysis, the n-3 LCPUFA group was 5.44 (1.15, 25.67) times more likely to have optimal cardiovascular health status after treatment. CONCLUSIONS: n-3 LCPUFA intake improved suboptimal cardiovascular health in this placebo-controlled, randomized, double-blind trial. TRIAL REGISTRATION: This study is registered at www.clinicaltrials.govNCT02103517.
Asunto(s)
Enfermedades Cardiovasculares/prevención & control , Suplementos Dietéticos , Aceites de Pescado/administración & dosificación , Estado de Salud , Enfermedades Metabólicas/tratamiento farmacológico , Adulto , Biomarcadores/sangre , Glucemia/efectos de los fármacos , Glucemia/metabolismo , Presión Sanguínea/efectos de los fármacos , Índice de Masa Corporal , Enfermedades Cardiovasculares/etiología , Distribución de Chi-Cuadrado , China , Suplementos Dietéticos/efectos adversos , Método Doble Ciego , Femenino , Aceites de Pescado/efectos adversos , Humanos , Lípidos/sangre , Modelos Logísticos , Masculino , Enfermedades Metabólicas/sangre , Enfermedades Metabólicas/complicaciones , Enfermedades Metabólicas/fisiopatología , Persona de Mediana Edad , Análisis Multivariante , Oportunidad Relativa , Factores de Riesgo , Factores de Tiempo , Resultado del TratamientoRESUMEN
Chitin was isolated from Kronopolites svenhedini and deacetylated to produce the derivative chitosan. The yield for chitin was 9%, and chitosan yield 57.4% and 77.5% respectively. After purification, their structures have been determined by spectroscopic methods.