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Bioorg Med Chem Lett
; 26(16): 4077-80, 2016 08 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-27397499
RESUMEN
In a search for novel small molecule calcium-sensing receptor (CaSR) antagonists as oral bone anabolic agents, we discovered dihydrobenzofuran cyclopropane carboxylic acid derivatives, such as 12f (IC50=27.6nM), are highly potent calcium-sensing receptor antagonists. Studies in rats established that compound 12f stimulates parathyroid hormone (PTH) release in a fast-acting, pulsatile manner.