RESUMEN
OBJECTIVE: To investigate the effects of atorvastatin combined with trimetazidine on periprocedural myocardial injury and serum inflammatory mediators in unstable angina pectoris (UAP) patients following percutaneous coronary intervention (PCI) treatment. PATIENTS AND METHODS: 90 patients with UAP treated with conventional medications and PCI were recruited and were randomly divided into the control group and the experimental group. The control group had 42 patients were treated with atorvastatin alone, while the experimental group had 48 cases treated with atorvastatin combined with trimetazidine. All the patients were checked the preoperative 24h and postoperative 24h PCI concentrations of cardiac troponin I (cTnI), hypersensitive C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), serum interferon-γ (IFN-γ) and interlukin-10 (IL-10). RESULTS: At the pre-PCI stage, every serum factors was no significant difference. 24 hours after the PCI intervention, the occurence of abnormal cTnI level in the experimental group was remarkable reduced than the control group. In the experimental group, the serum levels of TNF-α and IFN-γ significantly decreased (p < 0.05); while IL-10 was increased. In the control group, all the mediators were increased significantly except the hs-CRP (p < 0.05). CONCLUSIONS: No unexpected symptom was found in patients with large dose atorvastatin combined with large dose trimetazidine. The administration of conventional medications together with the atorvastatin plus trimetazidine were able to reduce the prevalence of postoperative myocardial injury.
Asunto(s)
Angina Inestable/tratamiento farmacológico , Angina Inestable/cirugía , Atorvastatina/administración & dosificación , Lesiones Cardíacas/epidemiología , Mediadores de Inflamación/sangre , Intervención Coronaria Percutánea/métodos , Trimetazidina/administración & dosificación , Anciano , Angina Inestable/sangre , Angina Inestable/epidemiología , Atorvastatina/efectos adversos , Proteína C-Reactiva/metabolismo , Terapia Combinada , Quimioterapia Combinada , Femenino , Lesiones Cardíacas/sangre , Humanos , Interferón gamma/sangre , Masculino , Persona de Mediana Edad , Periodo Perioperatorio , Complicaciones Posoperatorias/sangre , Complicaciones Posoperatorias/epidemiología , Trimetazidina/efectos adversos , Troponina I/sangre , Factor de Necrosis Tumoral alfa/sangreRESUMEN
A study of the chemical changes of phospholipid in crude and seven processed samples of Dioscorea opposita was carried out by molybdenum blue colorimetry and TLCS. The result shows that the total phospholipid content in the sample processed by honey bran comes out the highest (180.31 mg/100g).
Asunto(s)
Medicamentos Herbarios Chinos/química , Fosfolípidos/análisis , Cromatografía en Capa Delgada , Calor , Tecnología FarmacéuticaRESUMEN
Results of experiments showed that the contents of strychnine and brucine were about the same in decoction of Strychnos nux-vomica and S. pierriana, but the contents of vomicine, strychnine N-oxide and brucine N-oxide were greater in the former than in the latter. The contents of strychnine and brucine were greater under scalding with hot sand than deep-frying with sesame oil.