RESUMEN
Melanoma is the most aggressive form of skin cancer and there is a need for the development of effective anti-melanoma therapies as it shows high metastatic ability and low response rate. In addition, it has been identified that traditional phototherapy could trigger immunogenic cell death (ICD) to activate antitumor immune response, which could not only effectively arrest primary tumour growth, but also exhibit superior effects in terms of anti-metastasis, anti-recurrence for metastatic melanoma treatment. However, the limited tumour accumulation of photosensitizers/photothermal agents and immunosuppressive tumour microenvironment severely weaken the immune effects. The application of nanotechnology facilitates a higher accumulation of photosensitizers/photothermal agents at the tumour site, which can thus improve the antitumor effects of photo-immunotherapy (PIT). In this review, we summarise the basic principles of nanotechnology-based PIT and highlight novel nanotechnologies that are expected to enhance the antitumor immune response for improved therapeutic efficacy.
Asunto(s)
Melanoma , Neoplasias , Humanos , Fármacos Fotosensibilizantes/farmacología , Fármacos Fotosensibilizantes/uso terapéutico , Neoplasias/terapia , Melanoma/tratamiento farmacológico , Fototerapia , Inmunoterapia , Nanotecnología , Microambiente Tumoral , Línea Celular TumoralRESUMEN
<p><b>OBJECTIVE</b>To study and establish the fingerprints of Herba Senecionis Scandentis by RP-HPLC and LC-MS.</p><p><b>METHOD</b>C18 column was used in the HPLC separation. The mobile phase was composed of acetonitrile and 0.03% phosphoric acid with gradient elution. The flow rate was 1.0 mL m x min(-1) and detection wavelength was 254 nm.</p><p><b>RESULT</b>Under this selected chromatographic condition, good HPLC fingerprints of Senecio scandens were obtained.</p><p><b>CONCLUSION</b>HPLC fingerprint facilitate the evaluation of the quality of Herba Senecionis Scandentis.</p>
Asunto(s)
Asteraceae , Química , Cromatografía Líquida de Alta Presión , Métodos , Medicamentos Herbarios Chinos , Química , Reproducibilidad de los Resultados , Espectrometría de Masa por Ionización de Electrospray , MétodosRESUMEN
<p><b>OBJECTIVE</b>To isolate the constituents of Senecio scandens and determine their structures.</p><p><b>METHOD</b>Componds were isolated and purified by silica gel column chromatography and the structures were identified by spectroscopic methods.</p><p><b>RESULT</b>Nine compounds were isolated as lupenone (1) , oleanane (2) , beta-sitosterol (3) , daucosterol (4) , adonifoline (5) , phydroxy benzeneacetic acid (6) , 2-(1,4-dihydroxy-cyclohexanyl) -acetic acid (7), hyperoside (8), linarin (9).</p><p><b>CONCLUSION</b>These compounds were obtained from S. scandens for the first time except 4 and 6.</p>