RESUMEN
BACKGROUND: Curcumin, a polyphenolic chemical constituent derived from turmeric (Curcuma longa), has been shown to prevent gastric and colon cancers in rodents. Many mechanisms have been proposed for the chemopreventative effects, although the effect of curcumin on the growth of Helicobacter pylori has not been reported. H. pylori is a Group 1 carcinogen and is associated with the development of gastric and colon cancer. MATERIALS AND METHODS: A methanol extract of the dried powdered turmeric rhizome and curcumin were tested against 19 strains of H. pylori, including 5 cagA+ strains. RESULTS: Both the methanol extract and curcumin inhibited the growth of all strains of H. pylori in vitro with a minimum inhibitory concentration range of 6.25-50 micrograms/ml. CONCLUSION: These data demonstrate that curcumin inhibits the growth of H. pylori cagA+ strains in vitro, and this may be one of the mechanisms by which curcumin exerts its chemopreventative effects.
Asunto(s)
Curcuma/química , Curcumina/farmacología , Helicobacter pylori/efectos de los fármacos , Helicobacter pylori/crecimiento & desarrollo , Metanol/química , Pruebas de Sensibilidad Microbiana , Extractos Vegetales/farmacologíaRESUMEN
OBJECTIVE: To study the protective effects of Panax quinquefolium 20s-protopanaxdiolsaponins extracted from leaves of P. quinquefolium (PQDS) on acute myocardial infarction(AMI) in dogs. METHOD: The parameters of myocardial infart size, the serum CK and LDH activity, myocardial metabolism, free radicals and coronary circulation etc were determined by using the model of ligation of LAD in the anaesthetized open-chest dogs. RESULT: In dogs treated with PQDS(in a dosage of 10 and 20 mg.kg-1 i.v. infusion), the myocardial infarct size, the activity of serum CK, LDH and the contents of serum FFA and LPO were decreased, whereas the activity of serum SOD and GSH-Px increased markedly. At the same time, myocardial blood flow was increased and coronary vascular resistance decreased significantly. CONCLUSION: PQDS has protective effect on myocardial ischemia by modifying metabolic dysfunction of FFA, inhibiting oxygen free radical mediated peroxidation of membrane lipids, enhancing endogenous antioxidase activity and increasing myocardial blood supply.
Asunto(s)
Medicamentos Herbarios Chinos/farmacología , Ginsenósidos/farmacología , Infarto del Miocardio/fisiopatología , Panax/química , Animales , Circulación Coronaria/efectos de los fármacos , Creatina Quinasa/metabolismo , Perros , Medicamentos Herbarios Chinos/aislamiento & purificación , Femenino , L-Lactato Deshidrogenasa/metabolismo , Peróxidos Lipídicos/metabolismo , Masculino , Infarto del Miocardio/patología , Miocardio/patología , Hojas de la Planta/química , Plantas Medicinales/química , Distribución Aleatoria , Superóxido Dismutasa/metabolismoRESUMEN
Effects of saponin isolated from the leaves of Acanthopanax senticosus (ASS) on myocardial infarct size were studied in acute ischemic dogs. The results showed that ASS (in a dosage of 25.50 mg/kg, iv) could significantly reduce the sizes of acute myocardial infarcts and decline the serum CK and LDH activity at 6h after ligation of LAD. It could also decrease the serum FFA levels at 3h and 6h after LAD occlusion.
Asunto(s)
Medicamentos Herbarios Chinos/uso terapéutico , Infarto del Miocardio/tratamiento farmacológico , Miocardio/patología , Plantas Medicinales/química , Saponinas/uso terapéutico , Animales , Perros , Medicamentos Herbarios Chinos/química , Medicamentos Herbarios Chinos/toxicidad , Femenino , Masculino , Ratones , Infarto del Miocardio/metabolismo , Infarto del Miocardio/patología , Hojas de la Planta/químicaRESUMEN
The hypoglycemic effect of saponin isolated from the leaves of Acanthopanax senticosus (ASS) was studied. The results showed that ASS(100, 200 mg/kg, ip) could decrease various cases of experimental hyperglycemias induced by injection of adrenaline, glucose and alloxan, without affecting the levels of blood sugar in normal mice.
Asunto(s)
Glucemia/metabolismo , Medicamentos Herbarios Chinos/química , Hipoglucemiantes/farmacología , Saponinas/farmacología , Animales , Hipoglucemiantes/aislamiento & purificación , Ratones , Hojas de la Planta/química , Saponinas/aislamiento & purificaciónRESUMEN
A new pregnane glycoside, marsdekoiside A was isolated from the stems of Marsdenia koi (Asclepiadaceae) and its structure was elucidated from chemical and spectral data as 12-cinnamoyl-dihydrosarcostin-3-O-methyl-6-deoxy-beta-D-allopyr ano syl-(1----4)-O-beta-D-oleandropyranosyl-(1----4)-O-beta-D-++ +cymar opyranoside.
Asunto(s)
Anticonceptivos Femeninos/aislamiento & purificación , Medicamentos Herbarios Chinos/química , Pregnanos , Saponinas/aislamiento & purificación , Secuencia de Carbohidratos , Anticonceptivos Femeninos/química , Hidrólisis , Espectroscopía de Resonancia Magnética , Datos de Secuencia Molecular , Estructura Molecular , Saponinas/químicaRESUMEN
By random screening test, Marsdenia koi was found to have antifertility activity on SD rat. From MeOH extracts of this plant two steroidal glycosides, marsdekoiside A and B, were isolated, and their structures were elucidated on the basis of spectral evidence and by comparison of the hydrolysis products with the authentic samples. Both are newly identified compounds, and marsdekoiside A has good antifertility activity.
Asunto(s)
Anticonceptivos Femeninos/aislamiento & purificación , Medicamentos Herbarios Chinos/química , Pregnanos , Saponinas/aislamiento & purificación , Animales , Anticonceptivos Femeninos/química , Anticonceptivos Femeninos/farmacología , Femenino , Ratas , Ratas Endogámicas , Saponinas/química , Saponinas/farmacologíaRESUMEN
From the leaves and stems of Larrea tridentata six new furanoid lignans, compounds 1-6, have been isolated and their structures determined through interpretation of physical and spectroscopic properties. The use of 1D and 2D nOe experiments was of particular importance in assigning the stereochemistry.