RESUMEN
Alzheimer's disease (AD) and Parkinson's disease (PD) are two typical neurodegenerative diseases that increased with aging. With the emergence of aging population, the health problem and economic burden caused by the two diseases also increase. Phosphatidylinositol 3-kinases/protein kinase B (PI3K/AKT) signaling pathway regulates signal transduction and biological processes such as cell proliferation, apoptosis and metabolism. According to reports, it regulates neurotoxicity and mediates the survival of neurons through different substrates such as forkhead box protein Os (FoxOs), glycogen synthase kinase-3ß (GSK-3ß), and caspase-9. Accumulating evidences indicate that some natural products can play a neuroprotective role by activating PI3K/AKT pathway, providing an effective resource for the discovery of potential therapeutic drugs. This article reviews the relationship between AKT signaling pathway and AD and PD, and discusses the potential natural products based on the PI3K/AKT signaling pathway to treat two diseases in recent years, hoping to provide guidance and reference for this field. Further development of Chinese herbal medicine is needed to treat these two diseases.
RESUMEN
Discrimination methods of excess or deficient conditions of meridians in Huangdi Neijing (The Yellow Emperor's Canon of Internal Medicine) is studied and summarized in this paper. It indicates that the techniques of distinguishing described in the classic are extremely explicit. From comprehensive study of pulse on cunkou and Renying, syndromes classified according to meridians, inspection and palpation on meridians, excess or deficient conditions of meridians and collaterals can be accurately diagnosed. And it also has been approved by clinical practice that the application of discrimination techniques in Huangdi Neijing (The Yellow Emperor's Canon of Internal Medicine) in acupuncture practice is conductive to enhance the therapeutic effect of acupuncture therapy.