RESUMEN
Two new friedelane-type triterpenes, tripterfrielanons A (1) and B (2), along with six known triterpenoids, friedelin (3), canophyllal (4), canophyllalic acid (5), 3-oxo-29-hydroxyfriedelane (6), wilforlide A (7), wilforlide B (8), have been isolated from the EtOH extract of the roots of Tripterygiumwilfordii Hook.f. Compounds 4, 5, 6 were isolated for the first time from this plant. The new triterpenes 1 and 2 exhibited mild cytotoxic activity against human Hela cell lines in vitro. The assay showed the IC50 of 1 and 2 were 8.5 and 25 microg/mL, respectively.
Asunto(s)
Antineoplásicos Fitogénicos/farmacología , Fitoterapia , Extractos Vegetales/farmacología , Tripterygium , Antineoplásicos Fitogénicos/administración & dosificación , Antineoplásicos Fitogénicos/uso terapéutico , Células HeLa/efectos de los fármacos , Humanos , Concentración 50 Inhibidora , Extractos Vegetales/administración & dosificación , Extractos Vegetales/uso terapéutico , Raíces de Plantas , Triterpenos/administración & dosificación , Triterpenos/farmacología , Triterpenos/uso terapéuticoRESUMEN
OBJECTIVE: To study the chemical constituents of Ligularia vellerea. METHOD: The compounds were isolated by column chromatography, and the structures were identified by NMR spectral data and other methods. RESULT AND CONCLUSION: Seven compounds were isolated and identified as 4-hydroxyacetophenone, 8 alpha-hydroxy-7(11)-eremophilen-12, 8 beta-olide, umbelliferone, tiglic acid, 6 beta-hydroxy-7(11)-eremophilen-12, 8 alpha-olide, daucosterin, beta-sitosterol and stigmasterol. All the compounds were isolated for the first time from this plant.
Asunto(s)
Acetofenonas/aislamiento & purificación , Asteraceae/química , Plantas Medicinales/química , Umbeliferonas/aislamiento & purificación , Acetofenonas/química , Crotonatos/química , Crotonatos/aislamiento & purificación , Hemiterpenos , Raíces de Plantas/química , Rizoma/química , Umbeliferonas/químicaRESUMEN
The stability of liensinine injection was studied by accelarating test with classical isothermal method. Results of the study showed that the decomposition of the injection was found to be a first-order reaction. The activation energy was 75030 J.mol-1. The shelf life at 10 degrees C and 25 degrees C was predicted to be about 15 months and 3 months respectively. This experiment provides a reference for the storage of the injection.
Asunto(s)
Isoquinolinas/química , Fenoles/química , Cromatografía en Capa Delgada , Estabilidad de Medicamentos , Almacenaje de Medicamentos , Medicamentos Herbarios Chinos/química , InyeccionesRESUMEN
The content of liensinine in the green seed embryo of Nelumbo nucifera was determined by dual-wavelength TLC-scanning. The crude drug was extracted with two different method of impregnating and refluxing. The content of liensinine was determined to be 0.853% and 0.939% and the average recovery was 97.9% and 100.9% respectively.