RESUMEN
The active fraction extracted from dragon's blood displayed an inhibitory effect on alpha-glucosidase activity with an IC50 of 0.152 microg/mL, which is nearly half of the crude material. Its inhibition on alpha-glucosidase was noncompetitive. In addition, when this fraction was orally administered to mice dosed with Acarbose (20 mg/kg), the active fraction (100, 300, 500 mg/kg) significantly suppressed increase of blood glucose levels after sucrose loading in a dose-dependent manner. These results suggest that this extract from dragon's blood exerts an anti-diabetic effect by suppressing intestinal carbohydrate absorption and thereby reducing the postprandial increase of blood glucose.
Asunto(s)
Diabetes Mellitus Experimental/tratamiento farmacológico , Dracaena/química , Inhibidores de Glicósido Hidrolasas , Hipoglucemiantes/aislamiento & purificación , Extractos Vegetales/uso terapéutico , Acarbosa , Animales , Glucemia/efectos de los fármacos , Metabolismo de los Hidratos de Carbono/efectos de los fármacos , Diabetes Mellitus Experimental/inducido químicamente , Inhibidores Enzimáticos/uso terapéutico , Absorción Intestinal , RatonesRESUMEN
A new dihydrochalcone, 4'-hydroxy-4,2'-dimethoxy-dihydrochalcone, was isolated from Chinese dragon's blood, the red resin of Dracaena cochinchinensis. Its structure was established by spectrum analysis.