RESUMEN
OBJECTIVE: To assess clinical and microbiological outcomes of an Er:YAG laser in comparison with sonic debridement in the treatment of persistent periodontal pockets in a prospective randomized controlled multicentre study design. MATERIAL AND METHODS: A total of 78 patients in supportive periodontal therapy with two residual pockets were included, 58 were available for the whole follow-up period. Root surfaces were instrumented either with a sonic scaler (Sonicflex(®) 2003 L) or with an Er:YAG laser (KEY Laser(®) 3). Clinical attachment levels (CAL), Probing depths (PD), Plaque control record (PCR) and Bleeding on probing (BOP) were assessed at baseline, 13 and 26 weeks after treatment. In addition, microbiological analysis was performed employing a DNA diagnostic test kit (micro-IDent(®) Plus). RESULTS: Probing depths and CAL were significantly reduced in both groups over time (p < 0.05), without significant differences between the groups (p > 0.05). BOP frequency values decreased significantly within both groups (p < 0.05), with no difference between the laser and the sonic treatment (p > 0.05). PCR frequency values did not change during the observation period (p > 0.05). Microbiological analysis failed to expose any significant difference based on treatment group or period. CONCLUSION: Employing both sonic and laser treatment procedures during supportive periodontal care, similar clinical and microbiological outcomes can be expected.
Asunto(s)
Láseres de Estado Sólido/uso terapéutico , Terapia por Luz de Baja Intensidad/métodos , Desbridamiento Periodontal/métodos , Bolsa Periodontal/radioterapia , Carga Bacteriana/efectos de la radiación , Periodontitis Crónica/microbiología , Periodontitis Crónica/radioterapia , Periodontitis Crónica/terapia , Placa Dental/microbiología , Placa Dental/prevención & control , Femenino , Estudios de Seguimiento , Hemorragia Gingival/clasificación , Hemorragia Gingival/microbiología , Bacterias Gramnegativas/clasificación , Bacterias Gramnegativas/efectos de la radiación , Ondas de Choque de Alta Energía/uso terapéutico , Humanos , Terapia por Luz de Baja Intensidad/instrumentación , Masculino , Persona de Mediana Edad , Pérdida de la Inserción Periodontal/microbiología , Pérdida de la Inserción Periodontal/radioterapia , Pérdida de la Inserción Periodontal/terapia , Desbridamiento Periodontal/instrumentación , Bolsa Periodontal/microbiología , Bolsa Periodontal/terapia , Estudios Prospectivos , Sonicación/instrumentación , Raíz del Diente/microbiología , Raíz del Diente/patología , Raíz del Diente/efectos de la radiación , Resultado del TratamientoRESUMEN
The leaves of sage (Salvia officinalis L., Lamiaceae) contain high amounts of phenolic diterpenes such as carnosol and carnosic acid. These compounds display antioxidant and anti-inflammatory effects in vitro. Here, we have investigated the anti-inflammatory potency of a sage extract (SE) rich in phenolic diterpenes in vivo using the ultraviolet (UV) erythema test. In a prospective randomised double-blind placebo-controlled study, test areas on the backs of 40 healthy volunteers were irradiated with the 1.5-fold minimal erythema dose. Subsequently, the test areas were treated occlusively with 2% SE in a hydrophilic ointment, compared to 1% hydrocortisone and 0.1% betamethasone as positive controls, and the vehicle alone as placebo. Erythema values were measured photometrically prior to irradiation and after 48 hours. Compared to placebo, SE significantly reduced the ultraviolet-induced erythema, to a similar extent as hydrocortisone. These data suggest that SE might be useful in the topical treatment of inflammatory skin diseases.