RESUMEN
The first phytochemical investigation of Casearia graveolens twigs led to the isolation and identification of a new clerodane diterpene, caseariagraveolin (1), together with six known compounds (2-7). Their structures were elucidated by intensive analysis of their spectroscopic data. Compound 1 showed strong cytotoxicity against oral cavity and breast cancer cell lines with IC50 values of 2.48 and 6.63 µM, respectively.
Asunto(s)
Antineoplásicos Fitogénicos/química , Casearia/química , Diterpenos de Tipo Clerodano/química , Antineoplásicos Fitogénicos/farmacología , Línea Celular Tumoral , Diterpenos de Tipo Clerodano/farmacología , Humanos , Estructura MolecularRESUMEN
The volatile components of Murraya koenigii fresh leaves, collected from Surat Thani province, Thailand were studied by using headspace (HS) solid-phase microextraction (SPME) coupled with gas chromatography-mass spectrometry (GC-MS). The four fibers employed to extract the volatiles were polydimethylsiloxane (PDMS), polydimethylsiloxane-divinylbenzene (PDMS-DVB), carboxane-polydimethylsiloxane (CAR-PDMS) and polydimethylsiloxane-divinylbenzene-carboxane (PDMS-DVB-CAR). The volatile constituents of M. koenigii fresh leaves were also extracted by hydrodistillation and analyzed by GC-MS. Fifty-one compounds were identified by these fibers. Five major compounds, γ-terpinene, ß-caryophyllene, ß-phellandrene, a-selinene and a-pinene, were detected in all fibers. The PDMS-DVB-CAR fiber was considered as the best for trapping key volatiles of M. koenigii fresh leaves.
Asunto(s)
Cromatografía de Gases y Espectrometría de Masas/métodos , Murraya/química , Microextracción en Fase Sólida/métodos , Monoterpenos Ciclohexánicos , Ciclohexenos/análisis , Monoterpenos/análisis , Hojas de la Planta/química , Sesquiterpenos Policíclicos , Sesquiterpenos/análisisRESUMEN
Two new tetracyclo[7.3.3.3(3,11).0(3,7)]tetradecane-2,12,14-trione derivatives, cowabenzophenones A (1) and B (2), were isolated from ripe fruits of Garcinia cowa Roxb. Their structures were determined by spectroscopic methods. The tetracyclo[7.3.3.3(3,11).0(3,7)]tetradecane-2,12,14-trione skeleton from the Garcinia genus is reported for the first time.