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Opt Express ; 16(12): 8406-20, 2008 Jun 09.
Artículo en Inglés | MEDLINE | ID: mdl-18545554

RESUMEN

An alternative optical coherence tomography (OCT) to clinical ophthalmic 830 nm spectral-domain OCTs (SD-OCT) is demonstrated. An axial resolution of 7.4 microm, ranging depth of 4.2 mm in tissue, sensitivity of 98.5 dB, and detection speed of 38,300 axial scans/s have been achieved. These are comparable or superior to those of recently commercially available ophthalmic 830 nm SD-OCTs in clinics. In addition, fast volumetric imaging for the in vivo human posterior eye with high-contrast of the choroid is achieved. A broadband 1.04 microm light source enables the high-contrast and high resolution imaging of the retina and choroid. The ranging depth is extended by applying a full-range imaging method with an electro-optic modulator (BM-scan method). A prototype high-speed InGaAs line scan camera with 1024 pixels is used. A newly reported sensitivity improvement property of the BM-scan method demonstrates a sensitivity enhancement of 5.1 dB. We also introduce a newly developed resampling calibration method of spectrum that is independent of the intrinsic dispersion mismatch of the interferometer. The three-dimensional structure of the in vivo human optic nerve head with a very deep cupping is successfully visualized.


Asunto(s)
Coroides/citología , Aumento de la Imagen/instrumentación , Imagenología Tridimensional/instrumentación , Retina/citología , Retinoscopios , Tomografía de Coherencia Óptica/instrumentación , Humanos , Proyectos Piloto , Reproducibilidad de los Resultados , Sensibilidad y Especificidad
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