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Medicinas Complementárias
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1.
Eur J Pharmacol ; 945: 175605, 2023 Apr 15.
Artículo en Inglés | MEDLINE | ID: mdl-36822456

RESUMEN

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are a growing epidemic and the most common liver diseases. Consumption of a western diet with high fats alters redox status, induces inflammation, and impairs the physiological function of hepatocytes. However, the pharmacological market lacks anti-NAFLD/NASH drugs. Long pepper (Piper longum L) is used in traditional Mongolian medicine for treating hyperlipidemia. Piperlongumine (PL) is a bioactive compound of Piper longum L, which usually possesses anticancer activities due to its ROS elevation property. However, when PL was demethylated they behave as an antioxidant. Previously, we found dihydroxy piperlongumine (DHPL) possesses high antioxidant activity among the hydroxy piperlongumines, which makes us curious to reveal the anti-NAFLD effect. A high-cholesterol diet (HCD) was chosen to induce NAFLD zebrafish model, and the antioxidant and lipid-lowering effects of DHPL were evaluated. Histological alterations of NAFLD were also scored along with gene expression to explore the molecular mechanism. DHPL reduced lipid accumulation in both short-term and long-term feeding trials. DHPL increases antioxidant activity and lipid-lowering gene expression and decreases hepatic triglyceride, oxidative stress, and lipogenic genes. In conclusion, DHPL halted the progression of HCD-induced NAFLD in the zebrafish model.


Asunto(s)
Hipercolesterolemia , Hiperlipidemias , Enfermedad del Hígado Graso no Alcohólico , Animales , Enfermedad del Hígado Graso no Alcohólico/tratamiento farmacológico , Enfermedad del Hígado Graso no Alcohólico/etiología , Enfermedad del Hígado Graso no Alcohólico/prevención & control , Antioxidantes/uso terapéutico , Pez Cebra , Hígado/metabolismo , Hipercolesterolemia/tratamiento farmacológico , Hipercolesterolemia/metabolismo , Hipercolesterolemia/patología , Triglicéridos/metabolismo , Hiperlipidemias/tratamiento farmacológico , Colesterol/metabolismo , Dieta Alta en Grasa/efectos adversos
2.
Plant Physiol Biochem ; 110: 118-127, 2017 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-27622847

RESUMEN

This report focuses on application of zinc oxide nanoparticles (ZnONPs) carrying phycomolecule ligands as a novel plant growth promoter aimed at increasing the crop productivity. The present investigation examined the effect of ZnONPs on plant growth characteristics, and associated biochemical changes in cotton (Gossypium hirsutum L.) following growth in a range of concentrations (25-200 mg L-l ZnONPs) in combination with 100 mM P in a hydroponic system. Treated plants registered an increase in growth and total biomass by 130.6% and 131%, respectively, over control. Results demonstrated a significant increase in the level of chlorophyll a (141.6%), b (134.7%), carotenoids (138.6%), and total soluble protein contents (179.4%); at the same time, a significant reduction (68%) in the level of malondialdehyde (MDA) in leaves with respect to control. Interestingly, a significant increase in superoxide dismutase (SOD, 264.2%), and peroxidase (POX, 182.8%) enzyme activities followed by a decrease in the catalase (CAT) activity, in response to above treatments. These results suggest that bioengineered ZnONPs interact with meristematic cells triggering biochemical pathways conducive to an accumulation of biomass. Further investigations will map out the mode of action involved in growth promotion.


Asunto(s)
Gossypium/efectos de los fármacos , Nanopartículas del Metal/administración & dosificación , Fósforo/farmacología , Óxido de Zinc/farmacología , Biomasa , Carotenoides/metabolismo , Catalasa/metabolismo , Clorofila/metabolismo , Relación Dosis-Respuesta a Droga , Gossypium/crecimiento & desarrollo , Gossypium/metabolismo , Hidroponía/métodos , Malondialdehído/metabolismo , Meristema/efectos de los fármacos , Meristema/crecimiento & desarrollo , Meristema/metabolismo , Nanopartículas del Metal/química , Nanopartículas del Metal/ultraestructura , Microscopía Electrónica de Rastreo , Peroxidasa/metabolismo , Fósforo/química , Proteínas de Plantas/metabolismo , Espectrometría por Rayos X , Espectroscopía Infrarroja por Transformada de Fourier , Superóxido Dismutasa/metabolismo , Propiedades de Superficie , Difracción de Rayos X , Óxido de Zinc/química
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