RESUMEN
Ethanol extract of Terminalia pallida Brandis. (EETP) was evaluated for its anti-ulcer activity against various models of ulcers, such as drug-induced ulcers, histamine-induced ulcers and ethanol-induced ulcers in Swiss albino rats. The EETP at the doses of 250 and 500 mg/kg per os (p.o.) exhibited significant protection against ulcers produced by indomethacin, histamine and the effect was comparable to that of the reference drug famotidine (30 mg/kg b.w) orally. The extract also afforded significant protection against ethanol-induced gastric ulceration. Meanwhile, EETP significantly lowered the elevated lipid peroxide level (thiobarbituric acid reactive substances (TBARS)) and restored the altered glutathione level in ethanol-induced gastric ulceration. The present investigation revealed that the EETP exhibited significant anti-ulcer activity by enhancing antioxidant potential of the gastric mucosa, thereby reducing mucosal damage.
Asunto(s)
Antiulcerosos/uso terapéutico , Frutas , Fitoterapia , Extractos Vegetales/uso terapéutico , Úlcera Gástrica/tratamiento farmacológico , Terminalia , Animales , Antiulcerosos/aislamiento & purificación , Femenino , Peroxidación de Lípido/efectos de los fármacos , Masculino , Extractos Vegetales/aislamiento & purificación , Ratas , Úlcera Gástrica/inducido químicamente , Sustancias Reactivas al Ácido Tiobarbitúrico/metabolismoRESUMEN
The methanol extract of the whole plant of Vernonia cinerea (MEVC) was evaluated for its antipyretic potential on normal body temperature and yeast-induced pyrexia in rats. MEVC significantly reduced the normal body temperature at doses of 250 and 500 mg/kg body weight p.o. MEVC also lowered the elevated body temperature in the case of yeast-induced pyrexia in a dose dependent manner. The antipyretic effect of the extract at a dose of 500 mg/kg was identical to that of the standard drug paracetamol.
Asunto(s)
Analgésicos no Narcóticos/farmacología , Temperatura Corporal/efectos de los fármacos , Fiebre/prevención & control , Fitoterapia , Extractos Vegetales/farmacología , Vernonia , Administración Oral , Analgésicos no Narcóticos/administración & dosificación , Analgésicos no Narcóticos/uso terapéutico , Animales , Relación Dosis-Respuesta a Droga , Femenino , Masculino , Extractos Vegetales/administración & dosificación , Extractos Vegetales/uso terapéutico , Estructuras de las Plantas , Ratas , LevadurasRESUMEN
The methanol extract of the whole plant of Vernonia cinerea Less. was evaluated for its anti-inflammatory activity in acute (carrageenin, histamine and serotonin induced rat paw edema) and a chronic model (cotton pouch induced granuloma). The methanol extract (250 and 500 mg/kg(-1) p.o.) exhibited significant activity (p < 0.001) against all phlogistic agents used in a dose dependant manner. In the chronic model (cotton pouch granuloma method) the methanol extract exhibited significant anti-inflammatory activity. All these effects were compared with standard drug phenylbutazone (100 mg/kg(-1) p.o.).
Asunto(s)
Antiinflamatorios no Esteroideos/farmacología , Extractos Vegetales/farmacología , Vernonia , Animales , Carragenina , Edema/inducido químicamente , Edema/tratamiento farmacológico , Femenino , Miembro Anterior/efectos de los fármacos , Miembro Anterior/patología , Masculino , Fitoterapia , Ratas , Ratas WistarRESUMEN
The benzene extract of Vernonia cinerea showed a broad spectrum of antibacterial activity.
Asunto(s)
Antiinfecciosos/farmacología , Bacterias Gramnegativas/efectos de los fármacos , Bacterias Grampositivas/efectos de los fármacos , Fitoterapia , Extractos Vegetales/farmacología , Vernonia , Antiinfecciosos/administración & dosificación , Antiinfecciosos/uso terapéutico , Humanos , Pruebas de Sensibilidad Microbiana , Extractos Vegetales/administración & dosificación , Extractos Vegetales/uso terapéuticoRESUMEN
The effect of methanol extract of whole plants of Trichodesma indicum R. Br. has been investigated on sulphur dioxide (SO2) induced cough reflex in Swiss albino mice. The extract has demonstrated significant (p < 0.001) inhibition in frequency of cough in all the tested doses when compared with untreated control group. The effect persisted up to 90 min of its oral administration and also comparable to that of the effect exhibited by the standard drug (Codeine phosphate). This study confirmed the traditional use of this plant in the treatment of cough. Determination of underlying mechanism of beneficial effect is major topic requiring further comprehensive investigation.
Asunto(s)
Antitusígenos/farmacología , Boraginaceae , Fitoterapia , Extractos Vegetales/farmacología , Administración Oral , Animales , Antitusígenos/administración & dosificación , Antitusígenos/uso terapéutico , Cromatografía en Capa Delgada , Tos/inducido químicamente , Tos/tratamiento farmacológico , Relación Dosis-Respuesta a Droga , Femenino , Masculino , Ratones , Extractos Vegetales/administración & dosificación , Extractos Vegetales/uso terapéutico , Reflejo/efectos de los fármacos , Dióxido de AzufreRESUMEN
The methanol extract of the dried fruit powder of Terminalia pallida was evaluated for antimicrobial activity. The methanol extract showed a broad spectrum of antibacterial activity.
Asunto(s)
Antiinfecciosos/farmacología , Combretaceae , Bacterias Gramnegativas/efectos de los fármacos , Bacterias Grampositivas/efectos de los fármacos , Fitoterapia , Extractos Vegetales/farmacología , Antibacterianos , Aspergillus niger/efectos de los fármacos , Candida albicans/efectos de los fármacos , Frutas , Humanos , Pruebas de Sensibilidad MicrobianaRESUMEN
Petroleum ether and methanolic extracts of leaves of Eupatorium ayapana were tested for their antimicrobial activity. The petroleum ether extract showed higher antibacterial and antifungal activity than the methanolic extract.
Asunto(s)
Antiinfecciosos/farmacología , Asteraceae , Bacterias Gramnegativas/efectos de los fármacos , Bacterias Grampositivas/efectos de los fármacos , Fitoterapia , Extractos Vegetales/farmacología , Antibacterianos , Hongos/efectos de los fármacos , Humanos , Pruebas de Sensibilidad Microbiana , Hojas de la PlantaRESUMEN
The methanol extract of Urena lobata root showed a broad spectrum of antibacterial activity.