Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Más filtros

Bases de datos
País/Región como asunto
Tipo del documento
País de afiliación
Intervalo de año de publicación
1.
Nat Prod Res ; 32(11): 1357-1360, 2018 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-28641452

RESUMEN

The crude extract and fractions from the branches of Ixora brevifolia, a tree found in the Brazilian Cerrado, were tested for anti-inflammatory and in vitro antiproliferative effects. The crude extract and n-hexane fraction exhibited significant inhibition of ear oedema in mice, while n-hexane-precipitated and chloroform fractions strongly inhibited the myeloperoxidase activity in ear tissue. The n-hexane and n-hexane-precipitated fractions showed strong growth inhibition for glioma cell line and the hydromethanolic fraction inhibited the growth of leukaemia cell line.


Asunto(s)
Antiinflamatorios/farmacología , Antineoplásicos Fitogénicos/farmacología , Extractos Vegetales/farmacología , Rubiaceae/química , Animales , Antineoplásicos Fitogénicos/química , Brasil , Línea Celular Tumoral , Cloroformo/química , Ensayos de Selección de Medicamentos Antitumorales , Edema/tratamiento farmacológico , Glioma/tratamiento farmacológico , Glioma/patología , Células Hep G2 , Hexanos/química , Humanos , Ratones , Peroxidasa/metabolismo , Extractos Vegetales/química
2.
Nat Prod Res ; 27(18): 1677-81, 2013.
Artículo en Inglés | MEDLINE | ID: mdl-23387288

RESUMEN

The cytotoxic activity of crude extracts and their fractions from leaves and roots of G. pohliana was assessed against nine human cancer cell lines: melanoma (UACC-62), breast (MCF-7), breast expressing the multidrug resistance phenotype (NCI-ADR), lung (NCI-460), prostate (PCO-3), kidney (786-0), ovarian (OVCAR), colon (HT-29) and leukaemia (K-562). The hexane fraction from leaves (HL) and ethyl acetate (EAR), chloroform (CR) and hydromethanolic (HMR) fractions from roots were the most active fractions against K-562 with GI50 values being lower than 1 µg mL⁻¹. Also, CR and HMR fractions were active against UACC-62 cell line in the same order of magnitude. The phytochemical study of the CR fraction allowed identifying the known iridoids secoxyloganin, sweroside and loganin.


Asunto(s)
Antineoplásicos Fitogénicos/química , Antineoplásicos Fitogénicos/farmacología , Extractos Vegetales/química , Extractos Vegetales/farmacología , Rubiaceae/química , Línea Celular Tumoral , Células HT29 , Humanos , Glucósidos Iridoides/química , Glucósidos Iridoides/farmacología , Iridoides/química , Iridoides/farmacología , Hojas de la Planta/química , Raíces de Plantas/química
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA