Evaluation of therapeutic potential and anti-hyperchlostrolemic effects of prunes in albino rats: An experimental study.

Hyperlipidemia is a global epidemic that causes various cardiovascular diseases (CVDs). Prunes include fiber and numerous phenolic compounds that decrease cholesterol by decreasing LDL oxidation and supporting heart health. This study examined the therapeutic effects of Prunus domestica prunes on plasma fatty acids in albino rats after ingesting prune pulp. After chemical examination, prunes were proximately examined for nutritional content. Prunus domestica pulp was given to hyperlipidemic rats for two months in a clinical trial. 12 albino rates and divide into 3 groups. First group was controlled, others experimental. The study's 15th, 30th and 60th days evaluated lipid profile. The following study was analyzed using 2 way anova. Prunes have enough fiber, minerals and polyphenols to affect hyperlipidemic rats. GIII rats lower LDL, weight, and HDL more than GI and GII.

Investigating the effect of selenium nano-particles on microbial activity and cancerous cell line of MCF-7 and MDA-MB-231.

Selenium is a mineral that is essential to human health and is widely recognized for its responsibilities as a powerful anticancer vitamin and antibacterial vitamin. Selenium also plays a critical part in the production of vitamin D. The purpose of this research was to evaluate the particular effects that selenium nano-particles (SeNPs') had on the infectious agent Staphylococcus aureus as well as the breast cancer cell lines MCF-7 and MDA-MB-231. The proportion of MDA-MB-231 and MCF-7 cells that underwent late apoptosis was dramatically increased by selenium nanoparticles, whereas the number of cells that underwent cell expansion was significantly reduced. There was a wide range of variability in the effects of selenium nanoparticle treatment on cell growth apoptosis, apoptosis rates and patterns of cell cycle arrest. After 2, 4 and 6 hours, researchers found that the development of S. aureus was significantly reduced by selenium nanoparticles at doses of 8.0, 16.0 and 32g/mL. In addition to this, the presence of selenium nanoparticles resulted in a reduced percentage of bacteria that were still alive. According to the findings of the study, there is a need for more research into selenium nanoparticles with the intention of preventing and treating infections caused by S. aureus.

Investigation of phytochemical profiling and therapeutic effects of corn silk against diabetes in human male subjects.

The metabolic illness known as diabetes mellitus (DM) is brought on by a problem with insulin secretion, action, or both. Chronic hyperglycemia brought on by insulin insufficiency also causes abnormalities in the metabolism of proteins, fats and carbohydrates. Corn silk (Stigma maydis) has been used from centuries for treatment of many diseases like diabetes, hyper-uricemia, obesity, kidney stones, edema and many others. The female flower of Zea mays has an extended stigma that has historically been used to treat diabetes mellitus (DM). The objective of the current study was to evaluate how well corn silk lowers blood glucose levels. For this purpose, proximate, mineral and phytochemical profile of corn silk powder was analyzed. Afterwards human male subjects were divided into two groups G0 was a control group and G1 and G2 was an experimental group along with the dosage of 1 and 2g respectively. The effect of corn silk powder on blood sugar levels of male diabetic patients was checked every 7th day for 2 months and HbA1c test was done before and then after 60 days of clinical trial. The ANOVA results showed that random blood sugar level and HbA1c were highly significant.

Investigation the phytochemical profiling and therapeutic evaluation of ginger root powder against hypercholesterolemia and obesity.

Obesity is a metabolic disease that is characterized by increased caloric intake and decreased physical activity. Ginger (Zingiber officinale) is used as a spice that has potential role as an alternative medicine in a range of many diseases. The current research was carried out to explore the anti-obesity potential of ginger root powder. For this, the chemical and phytochemical characterization of ginger root powder were analyzed. Results showed that it contains moisture, ash content, crude fat, crude protein, crude fiber and nitrogen free extract 6.22±0.35, 6.37±0.18, 5.31±0.46, 1.37±0.15, 10.48±0.67 and 64.78±11.33mg/dl, respectively. Furthermore, the ginger root powder was given in the form of capsules to obese patients for the already designed treatment groups. The experimental groups (G1 and G2) were given ginger root powder capsules (3g) to G1 group and (6g) was given to G2 group for the time of 60 days. Results unveiled that G2 group showed highly significant change on waist to hip ratio (WHR) and the other parameters like (BMI, Body weight) and cholesterol showed slightly - significant change on both groups G1 and G2. It can be considered as an arsenal for fight against the health problems that have been raised from the obesity.

Explore the therapeutic potential and bioevaluation of giloy leaves (Tinospora cordifolia) powder for the management of type 2 diabetes.

Giloy (Tinospora cordifolia) is an important Ayurvedic medication. Numerous illnesses, including general senility, fever, diabetes, dyspepsia, urinary infections, jaundice and skin conditions are treated with it. The biological description and chemical components of cordifolia are critically reviewed in this essay, with a focus on its ayurvedic properties and pharmaceutical applications. The goal of the current study was to investigate the chemical, phytochemical and mineral profile and anti-diabetic potential of giloy leaves powder. The results showed that the moisture content was 6.2%, ash content was 13.12%, crude protein was 17.27% and fiber was 5.5%. While in mineral analysis, sodium was 22.12±1.78, magnesium was 15.78±1.70, calcium was 9.78±1.27, potassium was 32.24±1.40, iron was 8.37±1.078 and zinc was 4.87±0.89. Furthermore, total phenolic content was 156.78±1.18 and total flavonoid content was 45.78±0.57. Afterwards, the anti-diabetic potential was analyzed by givingthe giloy leaves powder to human experimental group G1 and G2 at adose of 400mg/kg and 800mg/kg, respectively. The effect of giloy leaves powder on diabetes patients' blood sugar levels was monitored every seventh day for 2 months and HbA1c tests were done initially and after 2 months. Random blood sugar and HbA1c were significant in ANOVA.