Antinociceptive activity of the Psidium brownianum Mart ex DC. leaf essential oil in mice.

Chronic pain management has several adverse effects and research looking for new and effective pain management drugs posing lower undesirable effects is necessary. Given the above, the pharmacological investigation of medicinal plants significantly contributes to the dissemination of plant-derived therapeutics. The aim of this study was to evaluate the antinociceptive activity of the Psidium brownianum Mart ex DC. leaf essential oil (PBEO) and the participation of the opioid pathway in this effect in mice. Swiss Mus musculus male mice were tested using acute nociception models (acetic acid induced abdominal contortions, formalin, capsaicin and hot plate tests). The possible myorelaxant action of the PBEO was tested using the rotarod test. The essential oil reduced animal nociception in chemical and heat models, with this action being devoid of a myorelaxant effect. Naloxone (2 mg/kg, intraperitoneally - i.p.) partially antagonized the PBEO activity, possibly acting via opioid receptors. The results obtained provide evidence that the traditional Psidium brownianum use may be effective for pain treatment.

Evaluation of the antioxidant and gastroprotective activity and HPLC analysis of the hydroalcoholic extract of Tocoyena formosa leaves (Cham. & Schlecht) K. Schum.

The peptic ulcer is a gastric disorder that affects millions of people and yet they cause many side effects. In this sense, natural products represent an important alternative to the discovery of compounds with gastroprotective activity. The present work has as its objective to evaluate the antioxidant and gastroprotective activity of the Hydroalcoholic Extract of Leaves from Tocoyena formosa (Cham. & Schlecht.) K. Schum (HELTF), this being much emphasized in traditional medicine for inflammatory morbidities and gastric symptoms. For the evaluation of the antioxidant activity, FRAP and DPPH tests were carried out, and for the evaluation of the gastroprotective activity, gastric lesion induction by ethanol, acidified ethanol, indomethacin and physical barrier tests were used. Antioxidant assay of HELTF revealed an EC50 of 558.66 µM FeSO4/g and IC50 of 189.78 µg/ml for FRAP and DPPH respectively. In gastroprotective, in ethanol model, all the doses presented significant activity in comparison to controls, however, in the gastric lesion induction test by acidified ethanol and indomethacin, only the dose of 200 mg/kg presented with significance. In the physical barrier test presented evidence that protection by the formation of a protective layer associated with mucus. Concluded, therefore, that HELTF possesses antioxidant and significate gastroprotective activity.

Atividade moduladora sobre antibióticos pelo extrato aquoso das folhas de Bauhinia ungulata L / Actividad modulador acerca de antibióticos por el extracto acuoso de las hojas de Bauhinia ungulata l / Modulatory activity about antibiotics by aqueous extract of the leaves of Bauhinia ungulata l

Introdução: cepas de Staphylococcus aureus, Escherichia coli e Pseudomonas aeruginosa são caracterizadas como importantes causadores de infeções bacterianas e destacam-se como um preocupante problema de saúde pública. A atividade antibacteriana de várias plantas tem sido estudada com a finalidade de diminuir a resistência microbiana existente com relação aos fármacos já industrializados. O gênero Bauhinia compreende cerca de 300 espécies que são conhecidas no Brasil como pata-de-vaca. A espécie Bauhinia ungulata Lin é bastante utilizada no controle glicêmico, mas, também, apresenta outras atividades, dentre elas é relatado uma ação antibacteriana. Objetivo: verificar o potencial modulador da espécie B. ungulata em associação a outros medicamentos já testados contra cepas de S. aureus, E. coli e P. aeruginosa. Métodos: as folhas da B. ungulata Lin foram coletadas no distrito de Arajara, Chapada do Araripe, estado do Ceará, Brasil. Foi utilizado o extrato aquoso das folhas de Bauhinia ungulata em associação aos antibióticos Amicacina, Gentamicina, Imipenem e Ciprofloxacino, esperando que o extrato agisse com antagonismo ou sinergismo frente ao efeito dos antibióticos. Resultados: o extrato das folhas de B. ungulata Lin apresentou relevante atividade sinérgica sobre os antibióticos utilizados (amicacina, gentamicina, imipenem e ciprofloxacino). Conclusão: portanto, o extrato em associação com os fármacos potencializou o efeito destes, revelando uma atividade antibacteriana significante(AU)

Introducción: las cepas de Staphylococcus aureus, Escherichia coli e Pseudomonas aeruginosa son causa importante de infecciones bacterianas y se destacan como un problema de salud pública. La actividad antibacteriana de varias plantas se ha estudiado con el fin de reducir la resistencia microbiana existente con respecto a los medicamentos ya industrializados. El género Bauhinia comprende alrededor de 300 especies que se les conoce en Brasil como pata-de-vaca. La especie Bauhinia ungulata Lin es ampliamente utilizada en control de la glucemia, pero también ofrece otras actividades, entre ellas es divulgado una acción antibacteriana. Objetivo: verificar el potencial modulador de las especies B. ungulata en asociación con otros fármacos probados contra cepas de S. aureus, E. coli y P. aeruginosa. Métodos: las hojas de B. ungulata Lin fueron recolectados en el distrito de Arajara, Chapada do Araripe, estado de Ceará, Brasil. Se utilizó el extracto acuoso de hojas de B. ungulata en asociación con antibióticos amikacina, gentamicina imipinem y ciprofloxacina, con la esperanza de que el extracto actúa con antagonismo o sinergismo, delantero de los efectos de los antibióticos. Resultados: el extracto de las hojas de B. ungulata Lin presenta relevante actividad sinérgica de los antibióticos utilizados (amikacina, gentamicina, ciprofloxacina y imipinem). Conclusión: el extracto en asociación con las drogas aumentó el efecto de estos, revelando una significativa actividad antibacteriana(AU)

Introduction: strains of Staphylococcus aureus, Escherichia coli e Pseudomonas aeruginosa are characterized as important causes of bacterial infections and stand out as a worrying public health problem. The antibacterial activity of several plants has been studied for the purpose of reducing the existing microbial resistance with respect to drugs already industrialized. The genus Bauhinia it comprises about 300 species they are known in Brazil as pata-de-vaca. The specie Bauhinia ungulata Lin is widely used in glycemic control, but also features other activities, among them is reported an antibacterial action. Objective: to verify the potential modulator of the species B. ungulata in association with other drugs tested against strains of S. aureus, E. coli and P. aeruginosa. Methods: The leaves of B. ungulata Lin were collected in the District of Arajara, Chapada do Araripe, Ceará state, Brazil. We used the water extract of leaves of B. ungulata in association with antibiotics amikacin, gentamicin, imipinem and ciprofloxacin, hoping that the extract acted with antagonism or synergism, front of the effects of antibiotics. Results: the extract of the leaves of B. ungulata Lin presented relevant synergistic activity about the antibiotics used (amikacin, gentamicin, ciprofloxacin and imipinem). Conclusion: therefore, the extract in association with the drugs increased the effect of these, revealing a significant antibacterial activity(AU)