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1.
Ethiop Med J ; Suppl 2: 9-20, 2013 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-24654505

RESUMEN

BACKGROUND: A 17 year old female patient who presented to a tertiary Hospital in Addis Ababa with bilateral painful leg swelling of two months and shortness of breath, associated with cough and haemoptysis of one week duration was reported to the Ministry of Health and the Addis Ababa Health Bureau. The condition was later detected in 18 individuals from 4 households indicating occurrence of an outbreak of unknown cause in Addis Ababa which lasted during May-July 2008. OBJECTIVE: An outbreak investigation was initiated to identify the cause and prevent further spread, morbidity and mortality. METHODS: Using semi-structured questionnaire, quantitative assessment involving individual cases and affected households was conducted to detect aetiology and risk factors. Unaffected households as well as unaffected members of affected households were also included for comparison purpose. Record review of patients visiting hospitals was also done. Data were collected through house to house visits, and using interview of cases admitted to hospital. Samples of cooking oil were collected for laboratory testing. Data analysis was done using SPSS. RESULTS: A total of 182 patients, 50 (27.5%) males and 132 (72.5%) females, were identified till the outbreak was controlled fully. Age varied from 6-90 years. Death was confirmed in 12 cases, 8 of whom were female. The majority of the patients came from the adjoining Lideta (39.0%) and Kolfe Keranyo (31.9%) subcities. History of illness ranged from less than a week to 12 weeks before presentation. Out of the 106 household members of the 24 affected households identified during the first phase of the investigation, 83 were affected. Most family members who infrequently take meals at home, and children aged 3 years and below were spared. The 21 visited affected households from Kolfe keranyo, Lideta and Bole subcities bought cooking oil produced by a firm in Lideta subcity and all had bought their last supplies in March and April 2008. Samples of cooking food oil taken from this firm and from the affected households were found to have alkaloids of Argemone Mexicana. The number of new cases dropped to zero within 6 weeks after the source was closed. CONCLUSION: The occurrence of bilateral leg swelling in more than one family member of affected households, that bought cooking oil from the same source, sparing the toddlers, and those who infrequently take meals at home, further strengthened by laboratory confirmation of presence of argemone alkaloids in the cooking oil samples taken from the affected households and the common sources led to the diagnosis of the outbreak to be epidemic dropsy.


Asunto(s)
Cardiotónicos/efectos adversos , Brotes de Enfermedades , Edema/epidemiología , Edema/terapia , Contaminación de Alimentos , Aceites de Plantas/efectos adversos , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Benzofenantridinas/efectos adversos , Niño , Análisis por Conglomerados , Edema/diagnóstico , Etiopía/epidemiología , Femenino , Humanos , Isoquinolinas/efectos adversos , Extremidad Inferior , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Factores de Riesgo , Adulto Joven
2.
Ethiop Med J ; Suppl 2: 21-32, 2013 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-24654506

RESUMEN

BACKGROUND: Food adulteration including adulteration of edible oils may cause serious health problems. One of the most common edible adulterants is argemone oil. An outbreak of epidemic dropsy occurred in Addis Ababa during May-June, 2008. One hundred and eighty two cases were recorded with twelve confirmed deaths. Dietary history of the cases revealed that vegetable oils were the usual cooking medium. OBJECTIVE: The aim of the study was hence to investigate the causes of this outbreak. METHODS: Contaminant identification was done using standard chemical tests, complemented with TLC. Toxicity study was done using Swiss albino mice feed with contaminated and non contaminated standard diet for 30 days. RESULTS: Laboratory investigation of the edible oils has indicated that 47 of the 280 edible oils analyzed were adulterated with argemone oil. About 81% of the edible oil samples collected from Lideta sub-city were adulterated with argemone oil. Toxicological investigation of the adulterated oils also indicated typical features of argemone alkaloid poisoning in mice. CONCLUSION: Results of both laboratory analysis and toxicological studies confirmed consumption of edible oils adulterated with argemone oil as the cause of epidemic dropsy in Addis Ababa.


Asunto(s)
Cardiotónicos/efectos adversos , Brotes de Enfermedades , Edema/epidemiología , Edema/terapia , Contaminación de Alimentos , Aceites de Plantas/efectos adversos , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Animales , Benzofenantridinas/efectos adversos , Benzofenantridinas/toxicidad , Cardiotónicos/toxicidad , Niño , Encuestas sobre Dietas , Edema/diagnóstico , Etiopía/epidemiología , Femenino , Humanos , Isoquinolinas/efectos adversos , Isoquinolinas/toxicidad , Extremidad Inferior , Masculino , Ratones , Persona de Mediana Edad , Aceites de Plantas/toxicidad , Factores de Riesgo , Pruebas de Toxicidad , Adulto Joven
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