[Effects of the beta-stimulating training in recovery of adaptive reserves in athletes of different sports]. / Effekty beta-stimuliruyushchego treninga v vosstanovlenii adaptatsionnykh rezervov u sportsmenov s raznoi napravlennost'yu trenirovochnogo protsessa.

Application of the beta rhythm neurofeedback is mainly dealt with when considering issues related to improving attention for clinical or preventive purposes. Cognitive and autonomic interactions formed with the help of biofeedback training, changing the function of autonomic and visceral systems, qualitatively improve the efficiency of any activity, including athletic activity, the nature of which is predetermined by the type of sports. OBJECTIVE: To identify effects of the beta-stimulating training in recovery of adaptive reserves in athletes of different sports. MATERIAL AND METHODS: The study included young male athletes aged 18-22 years (n=1020), distributed according to the type of sports: group 1 - cyclic sports (n=387); group 2 - speed-strength sports (n=255); group 3 - single combat (n=31); group 4 - team sports (n=173); group 5 - complex-coordination sports (n=174). The main objective of the beta-stimulating training was to select a strategy to raise the beta rhythm level while muscles were relaxed. For each group, we identified training efficiency periods according to the lowest value of the attention index (θ/ß, c.u.), then we examined distribution of brain rhythms (α, %; ß, %; θ, %) according to EEG. The level of adaptive reserves was identified according to the heart rate variability (HRV) spectral analysis («VNS-Spektr¼, Neurosoft, Ivanovo). RESULTS: We identified following periods of the beta-stimulating training efficiency according to the attention index (θ/ß, c.u.): group 1 - 10th session (game variant); group 2 - 5th session (graphic and game variants); group 3 - 1st and 10th sessions (game variant), 5th session (graphic variant); group 4 (game variant) - 1st, 5th and 10th sessions; group 5 (game variant) - 5th and 10th sessions. The efficiency periods in the observed groups were accompanied by the following distribution of rhythms in the EEG structure: ß-rhythm - 45-60%; θ-rhythm - 20-35%, α-rhythm - 19-25%. During these periods, wave structure of the heart rhythm also changed: the activity of VLF waves increased (%); the proportion of HF waves decreased in the range of 23.3-31.59% in the groups 1, 2 and 3; the share of HF waves increased in the range of 32.3-39.8% in the group 4 at the 1st session and in the group 5 at the 10th session. The values of total power (TP, ms2) reduce at the 10th session in the groups 1, 3 and 4 and at the 5th session in the group 5. The vagosympathetic balance coefficient (LF/HF, c.u.) in the studied groups corresponds to the range of normal values; the values increased in the group 2 at the 5th session, in the groups 3 and 4 - at the 5th and 10th sessions, in the 5th group - at the 5th session. The index decreased in the groups 3 and 4 at the 1st session. The index was stable in the groups 1 and 5 at the 10th session of the training. CONCLUSION: Periods of the beta-stimulating training efficiency associated with the improvement of attention according to the lowest values of θ/ß (c.u.) are accompanied by changes in the modulation of the structure of brain rhythms and the wave structure of heart rate variability, optimizing the psychophysiological state of athletes depending on the type of sport, the number of sessions completed and the session variants chosen.

[Methods to restore fine motor skills in stroke patients]. / Metody vosstanovleniya tonkoi motoriki u patsientov, perenesshikh insul't.

The review article considers the problem of nonmedical post-stroke rehabilitation, in particular the restoration of fine motor skills in patients in the early period of the disease. A review and analysis of various randomized controlled trials concerning the use of various rehabilitation methods both in monotherapy and in their combined application is carried out, and modern technical devices, with the use of computer technology and biofeedback, are reviewed. Proceeding from the presented literature data and their analysis, there are certain grounds for introducing modern apparatus complexes and robotized devices for fine motor skills restoration in post-stroke patients, especially in the early period, into the multimodal rehabilitation system. However, further research in this direction is needed to achieve a sustained positive result.

[Myostimulating effect of comprehensive application of general magnetotherapy, fractional CO2 laser, electro-myostimulation and special complex of exercise in patients with rectoceleal after open-peconstructure]. / Miostimuliruyushchii effekt kompleksnogo primeneniya obshchei magnitoterapii, fraktsionnogo CO2-lazera, elektromiostimulyatsii i spetsial'nogo kompleksa LFK u patsientok s rektotsele posle rekonstruktivno-plasticheskikh operatsii.

The article presents data on the treatment of 200 women of childbearing, peri - and menopausal age with rectocele of II-III degree, which were divided into 4 groups comparable in clinical and functional characteristics: 1-50 patients who, after surgical treatment of rectocele, underwent a complex consisting of a course of General magnetic therapy, 2 intra-vascular procedures of fractional microablative CO2 laser therapy, electromyostimulation with the pelvic floor muscles and a special complex of therapeutic physical education; comparison 1, which included 50 patients who underwent the above-mentioned complex of rehabilitation measures without General magnetotherapy; comparison of 2-50 patients after surgical treatment of rectocele, who in the late postoperative period (one month after the operation) underwent a set of rehabilitation measures, including a course of electromyostimulation with the biological connection of the pelvic floor muscles, consisting of 10 daily procedures and a special complex of physical therapy and a control group - 50 patients after surgical treatment of rectocele, who in the late postoperative period were treated with symptomatic therapy, including painkillers and antispasmodics, which served as a background for all other groups. As a result of the research, it was found that the developed rehabilitation complexes have a pronounced myostimulating effect, and can be recommended for wide use in rehabilitation programs for postoperative management of patients with rectocele.

[Complementary methods of rehabilitation in borderline mental disorders].

The article covers treatment results of 417 patients (186 males and 231 females) aged 18 to 71 years, with borderline mental disorders. Findings are that using specified complementary methods, more when treatment complex is applied, causes better psycho-emotional state in patients with borderline mental disorders, that is supported by results of medical diagnostic tests including psychometry tests (abridged minnesota multiphasic personality inventory, Beck depression inventory, Spielberger-Hanin, test "feeling, activity, mood").

[Enhancement of measles-mumps divaccine using myelopeptide 2 in experiment].

Combined application of mumps and measles vaccine strains in equal doses results in significant decrease of immune response to the former component in humans. It is possible that this phenomenon is related with well-known immunodepressive effect of measles virus, which was demonstrated both in vivo and in vitro. It was previously shown that myelopeptide-2 (MP-2) partially neutralizes suppressive effect of measles vaccine on blast transformation of activated human lymphocytes in vitro. Partial supression of immune response to mumps vaccine by live measles vaccine was reproduced in laboratory animals. It was shown that in experiment MP-2 partially neutralized suppressive effect of measles vaccine.

[Effect of myelopeptide 2 on the immunization of guinea pigs with live measles vaccine]. / Vliianie mielopeptida 2 na rezul'taty immunizatsii morskikh svinok zhivoi korevoi vaktsinoi.

A model is suggested to study the effects the myelopeptide 2 (MP2) immunomodulator on the results of live measles rash immunized by vaccine. Guinea pigs were found to respond to live measles vaccine L-16 the way man does, i.e. the antibodies' level in their sera was increasing until days 28-56 after a single intramuscular vaccine injection. An intramuscular injection of the MP2 immunomodular, made alongside with vaccination, was demonstrated to enhance the immune response to the measles vaccine and to induce its action. Finally, it was for the first time, that the possibility was proven to enhance the action of the live measles vaccine by an immunomodulator.

[The analgesic effect of various fractions of the supernatant of a bone marrow cell culture in pathologic pain]. / Analgeziruiushchii éffekt razlichnykh fraktsii supernatanta kul'tur kletok kostnogo mozga pri patologicheskoi boli.

Different fractions of bone marrow cell culture supernatant effects on pathological pain have been studied. It is shown that all studied fractions have analgesic effect and inhibit strong pain syndrome induced by generator of pathologically enhanced excitation. In distinction from commercial drug myelopid bone marrow supernatant fractions with high and low molecular weight exert analgesic effect in low concentrations not having muscle-relaxant and narcotic influence. It suggests the possibility of creation of some new highly effective analgesic drugs to abolish pain syndromes.

[The immunomodulating action of myelopeptides in hypoxic hypoxia in animals]. / Immunomoduliruiushchee deistvie mielopeptidov pri gipoksicheskoi gipoksii u zhivotnykh.

It was observed that in animals which underwent a hypoxic stress by way of a 3-day exposition in the pressure chamber at an altitude of 7,000 m the immune response to sheep erythrocytes was decreased by 47 per cent. A two-three-fold decrease in the production of myelopeptides was noted in 24h after the exposition in the pressure chamber.

[Reflexotherapy of asthenic conditions in neuroses]. / Refleksoterapiia astenicheskikh sostoianii pri nevrozakh.

The results of clinico-psychological examination of 121 patients have demonstrated that acupuncture is a fairly effective method of treating asthenic states in neurotic patients. Thus, considerable improvement and improvement has been observed in 67% of the patients. The absence of positive effect in the remaining cases is explained by an aggravated history, a stubborn course of the disease, and depletion of the functional activity of the sympathoadrenal system (SAS) and the adrenal cortex. Normalization of EEG rhythm is effected through activation of the synchronizing and inactivation of the desynchronizing cerebral systems; the positive dynamics of the structure of nocturnal sleep is reflected in an increased duration of slow sleep and rapid sleep which were initially reduced, in more regular alternation of the cycles and phases of sleep, and in a shorter period of falling asleep. Biochemical examinations have revealed activation of the mediatory component of the SAS and elevation of the function of the adrenal cortex, while baroalgesimetric studies have shown that acupuncture is characterized by antinociceptive and activizing effects. On the whole the efficacy of acupuncture in controlling asthenic conditions related to neuroses is due to its integral action.

[Serotoninergic and catecholaminergic indices in patients with neurotic and depressive disorders and changes in them as a result of reflexotherapy]. / Serotoninergicheskie i katekholaminergicheskie pokazateli u bol'nykh s nevroticheskimi depressivnymi rasstroistvami i ikh izmeneniia pod vliianiem refleksoterapii.

The status of the serotoninergic and catecholaminergic systems was studied in patients with neurotic depressive disorders before and after acupuncture (AP). The parameters studied included blood serotonin levels, monoamine oxidase (MAO) activity in the blood serum, as well as urinary excretion of adrenaline, noradrenaline, dopamine, DOPA and 5-HOIAA. Prior to AP patients with anxiety-depressive, depressive-hypochondriac or asthenodepressive manifestations showed different changes in the parameters studied. Following a course of AP they presented a compensatory increase in MAO activity, normalization of blood serotonin levels and of the urinary excretion of noradrenaline, dopamine and DOPA. Improvement in biochemical parameters indicates that this type of therapy is an effective means of the treatment of patients with neuroses with the predominance of depressive disorders.

[Relation between clinico-physiologic indices of sleep and the nature of stress and reflexotherapy application]. / Zavisimost' kliniko-fiziologicheskikh pokazatelei sna ot kharaktera stressa i refleksoterapevticheskogo vozdeistviia.

The time-course of the structure of nocturnal sleep in normal subjects in conditions of a single sleep deprivation (acute sleep deprivation) and in neurotic patients with chronic sleep deprivation has been studied. The efficacy of acupuncture under different conditions is analyzed. The results obtained suggest a differential nature of the acupuncture effect in conditions of acute and chronic sleep deprivation. In acute sleep deprivation in normal subjects electrical acupuncture activates both synchronizing and desynchronizing mechanisms of the cerebral nonspecific systems. In chronic disturbances of sleep associated with neuroses acupuncture activates the synchronizing systems and inhibits the cerebral deactivating systems. Preventive acupuncture is recommended as a method increasing the activity of people working on night shifts (operators, traffic controllers, etc.).

[Reflexotherapy of neurotic patients with depressive-hypochondriacal manifestations]. / Refleksoterapiia bol'nykh nevrozami s depressivno-ipokhondricheskimi proiavleniiami.

Forty-one neurotic patients with pronounced depressive-hypochondriac symptomatology were treated by acupuncture. A decrease in the psychoemotional and algetic symptoms (sleep restoration, increased working capacity) following acupuncture was attended by certain changes in the nocturnal and diurnal EEG with the prevailing activation of the synchronizing mechanisms of nonspecific brain systems which suggests that the structures of the thalamo-cortical and nonspecific cerebral level are involved in the realization of the acupuncture therapeutic effect and that it is advisable to activate the synchronizing cerebral mechanisms.