1.
The discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors.
Bioorg Med Chem Lett
; 21(4): 1248-52, 2011 Feb 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-21211972
RESUMEN
Virtual and high-throughput screening identified imidazo[1,2-a]pyrazines as inhibitors of B-Raf. We describe the rationale, SAR, and evolution of the initial hits to a series of furo[2,3-c]pyridine indanone oximes as highly potent and selective inhibitors of B-Raf.