RESUMEN
Urothelial carcinoma with villoglandular differentiation (UCVGD) is a rare aggressive variant of urothelial carcinoma. It is usually associated with high-grade urothelial carcinoma or rarely adenocarcinoma. There is only one other previous report of UCVGD associated with small cell neuroendocrine carcinoma of urinary bladder. We report the second case of UCVGD with small cell neuroendocrine carcinoma of urinary bladder in a 74-year-old non-smoker male patient. The mass was muscle invasive and also invaded the prostate. This entity needs to be confidently diagnosed due to its prognostic and therapeutic implications.
Asunto(s)
Carcinoma Neuroendocrino/diagnóstico por imagen , Carcinoma de Células Pequeñas/diagnóstico por imagen , Carcinoma de Células Transicionales/diagnóstico por imagen , Próstata/patología , Neoplasias de la Vejiga Urinaria/diagnóstico por imagen , Anciano , Carcinoma Neuroendocrino/patología , Carcinoma Neuroendocrino/terapia , Carcinoma de Células Pequeñas/patología , Carcinoma de Células Pequeñas/terapia , Carcinoma de Células Transicionales/patología , Carcinoma de Células Transicionales/terapia , Cistoscopía , Diagnóstico Diferencial , Quimioterapia , Humanos , Masculino , Terapia Neoadyuvante , Clasificación del Tumor , Invasividad Neoplásica , Próstata/cirugía , Tomografía Computarizada por Rayos X , Resección Transuretral de la Próstata , Neoplasias de la Vejiga Urinaria/patología , Neoplasias de la Vejiga Urinaria/terapiaRESUMEN
BACKGROUND: Neonatal acute liver failure (NALF) is often a fatal condition. Zygomycosis is a fungal infection that is often fatal in both adults and infants. Only a few cases of hepatic zygomycosis are reported in the literature and they are invariably associated with immunosuppression. MATERIALS AND METHODS: Post-mortem liver biopsy from a 14-day old neonate demonstrated confluent panacinar necrosis with angioinvasive zygomycosis. The limited work-up could not rule out an underlying immunodeficiency. CONCLUSION: Angioinvasive hepatic zygomycosis can present in the neonatal period as NALF.