The preventive effects of Ulva lactuca aqueous extract, ulvan polysaccharides and atorvastatin on ethylene glycol-induced hyperoxaluria.

OBJECTIVE: Kidney stones are a common complication of hyperoxaluria. The aim of this study is to investigate the protective and preventive effects of Ulva lactuca aqueous extract, ulvan polysaccharides and atorvastatin on ethylene glycol-induced hyperoxaluria. MATERIALS AND METHODS: Male Wistar rats between 110 and 145 g in weight were used in the study, Ulva lactuca aqueous extract and polysaccharides were prepared. The male albino rats were supplemented with 0.75 percent ethylene glycol (v/v) in their drinking water for six weeks to induce hyperoxaluria. Ulvan infusions (100 mg/kg body weight), ulvan polysaccharides (100 mg/kg body weight), and atorvastatin (two milligrams/kg body weight) to treat hyperoxaluric rats for four weeks (every other day) were used. Weight loss, serum creatinine, serum urea, serum uric acid, serum oxalate, kidney oxalate, kidney lipid peroxidation, and kidney DNA fragmentation and kidney histopathological studies were done. RESULTS: Weight loss, rise of serum creatinine, serum urea, serum uric acid, serum oxalate, kidney oxalate, kidney lipid peroxidation, and kidney DNA fragmentation were all shown to be prevented by the addition of atorvastatin, polysaccharides, or aqueous extract, respectively. Catalase (CAT) activity, glutathione peroxidase (GPX) activity, glutathione-S-transferase (GST) activity, and histopathological perturbations were all significantly reduced by the medicines that were studied. CONCLUSIONS: Hyperoxaluria caused by ethylene glycol may be prevented by a combination of Ulva lactuca aqueous extract, ulvan polysaccharides, and atorvastatin. A reduction in renal oxidative stress and an improvement of the antioxidant defense system may be responsible for these protective benefits. However, Ulva lactuca infusion and ulvan polysaccharides need to be studied further in humans, in order to determine their efficacy and safety.

Analyzing the influence of the combination of monochromatic infrared energy and tai chi exercise improve balance in community-dwelling older adults with lower-extremity disease: a double-blinded randomized controlled study.

OBJECTIVE: This study aimed to evaluate the efficacy of a combination of MIRE exposure and Tai Chi exercise on balance and fall risk in community-dwelling older adults with lower-extremity disease (LED). PATIENTS AND METHODS: In this double-blinded randomized controlled study, 49 older adults were randomly allocated into the MIRE group (n=25), in which the participants were exposed to 30 min of MIRE and performed 40-45 min of Tai Chi exercise, three sessions/week; and the sham group (n=24), in which the participants only performed the Tai Chi exercise. We measured the ankle/brachial index (ABI), as well as scores of the Berg balance scale (BBS), Tinetti clinical scale (TCS), and Timed Up and Go Test (TUG) before and after 3-months of intervention. RESULTS: A significant increase in ABI and scores of BBS, and TCS, was observed, along with a significant decrease in TUG scores in the MIRE group. The sham group showed a significant increase in the ABI, and TCS score, and a significant decrease in the TUG score, with a non-significant change in the BBS score. Comparison between both study groups illustrated that the patients in the MIRE group experienced improved balance and decreased fall risk. CONCLUSIONS: Three months of MIRE exposure and Tai Chi exercise improved balance and reduced the risk of falls in community-dwelling older adults with LEDs.