RESUMEN
PURPOSE: To evaluate the effectiveness of systemic enzyme therapy for the control of edema in patients who undergo bimaxillary orthognathic surgery. MATERIALS AND METHODS: Thirty patients were included in this double-blinded, randomized, control trial. Before surgery, each patient was allotted a code (study or control group). Nine anthropometric points were selected. Thickness of the soft tissue at each of these points was measured using an ultrasound device. These measurements were performed on the day before surgery and 1, 5, and 15 days after surgery. The study group was given a twice-daily dose of systemic enzyme therapy from the first postoperative day for 5 days; the control group was given placebo. The percentage of difference in the thickness of the soft tissue was calculated at each of the 9 points on postoperative days 1, 5, and 15. These data were analyzed and compared using the Mann-Whitney test. RESULTS: The statistical evaluation showed a significant difference in soft tissue thickness between the 2 groups, especially on days 5 and 15, at most assessed points. CONCLUSION: The results of this study suggest that systemic enzyme therapy significantly decreases postoperative edema in orthognathic surgery, precluding long-term corticosteroid use.
Asunto(s)
Edema/prevención & control , Endopeptidasas/uso terapéutico , Terapia Enzimática/métodos , Cara , Procedimientos Quirúrgicos Ortognáticos/métodos , Complicaciones Posoperatorias/prevención & control , Rutina/uso terapéutico , Bromelaínas/uso terapéutico , Cefalometría/métodos , Mentón/diagnóstico por imagen , Mentón/cirugía , Método Doble Ciego , Combinación de Medicamentos , Edema/diagnóstico por imagen , Cara/diagnóstico por imagen , Femenino , Estudios de Seguimiento , Humanos , Labio/diagnóstico por imagen , Masculino , Mandíbula/diagnóstico por imagen , Cuello/diagnóstico por imagen , Osteotomía Le Fort/métodos , Osteotomía Sagital de Rama Mandibular/métodos , Placebos , Complicaciones Posoperatorias/diagnóstico por imagen , Premedicación , Estudios Prospectivos , Resultado del Tratamiento , Tripsina/uso terapéutico , Ultrasonografía , Adulto JovenRESUMEN
OBJECTIVES: The objective of this study was to study the effects of meditation on stress-induced changes in cognitive functions. METHODS: The study was conducted on 32 healthy adult male student volunteers who had never practiced meditation before the study. The study consisted of practicing 20 minutes of guided meditation and administration of psychologic stress to the subjects. The psychologic stress was administered to the subjects by asking them to play a (preselected) stressful computer game. The subjects were asked to meditate either before or after the administration of psychologic stress. For the control group measurements, the subjects were asked to wait quietly for an equivalent period of meditation time. OUTCOME MEASURES: The outcome measures were galvanic skin response (GSR), heart rate (HR), electromyography (EMG), sympathetic reactivity (QTc/QS2 ratio), cortisol, and acute psychologic stress scores. The central nervous system functions were assessed using Wechsler memory scale and visual-choice reaction time (VCRT). These parameters were measured both at the beginning and at the end of the intervention, using a pre-post experimental test design. RESULTS: Computer game stress was associated with a significant increase in physiologic (GSR, EMG, HR, QTc/QS2) and psychologic (acute stress questionnaire scores) markers of stress. Meditation was associated with relaxation (significant decrease in GSR, EMG, QTc/QS2, and acute stress questionnaire scores). Meditation, if practiced before the stressful event, reduced the adverse effects of stress. Memory quotient significantly increased, whereas cortisol level decreased after both stress and meditation. VCRT showed no significant change. CONCLUSIONS: Practice of meditation produced a relaxation response even in the young adult subjects who had never practiced meditation before. The practice of meditation reduced the physiologic stress responses without taking away the beneficial effect of stress, namely, improved memory scores.