RESUMEN
Flavaglines are cyclopenta[b]benzofurans found in plants of the genus Aglaia, several species of which are used in traditional Chinese medicine. These compounds target the initiation factor of translation eIF4A and the scaffold proteins prohibitins-1 and 2 (PHB1/2) to exert various pharmacological activities, including antiviral effects against several types of viruses, including coronaviruses. This review is focused on the antiviral effects of flavaglines and their therapeutic potential against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Asunto(s)
Aglaia/química , Antivirales/uso terapéutico , Productos Biológicos/uso terapéutico , Infecciones por Coronavirus/tratamiento farmacológico , Factor 4A Eucariótico de Iniciación/genética , Neumonía Viral/tratamiento farmacológico , Proteínas Represoras/genética , Animales , COVID-19 , Factor 4A Eucariótico de Iniciación/efectos de los fármacos , Humanos , Medicina Tradicional China , Pandemias , Prohibitinas , Proteínas Represoras/efectos de los fármacosRESUMEN
Langerhans cells are specialized sentinels present in the epidermis expressing Langerin, a specific C-type lectin receptor involved in HIV capture and destruction. Recently, the specific mechanism leading to this HIV restriction was discovered. Nevertheless, Langerhans cells can be infected and the way HIV escapes this restriction needs to be unraveled.