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Medicinas Complementárias
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1.
Allergy ; 55(9): 818-26, 2000 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-11003445

RESUMEN

BACKGROUND: Evaluation of the efficacy of allergen-specific immunotherapy (IT) with pollen extracts is complicated by annual variation in pollen intensity. Our study aimed to evaluate the efficacy of birch and grass IT, taking into consideration these variations. METHODS: After 1 year of observation, 52 patients with rhinoconjunctivitis and allergy to birch as well as grass pollen were allocated to double-blinded clustered IT with aluminum-adsorbed extract produced from either birch (Betula verrucosa) pollen or grass (PIleum pratense) pollen. After 1 year of treatment, the patients continued IT with their original extract and also received the other extract. During the three consecutive pollen seasons, the rhinoconjunctivitis symptom score and the use of antihistamines, eye-drops, and oral prednisolone were recorded. Longitudinal data analysis was used to investigate the relation between different pollen counts and the magnitude of clinical efficacy. RESULTS: An effect of IT was found on symptom score, antihistamine intake, and eye-drop use for both birch and grass (P values <0.05). The mean reduction in symptom score/medication by IT ranged from 24% to 95%, depending on mean seasonal pollen counts. A minimum mean seasonal grass-pollen count of 20-30 pollen grains m3 was required for the efficacy of grass IT to emerge. CONCLUSIONS: A model was developed for evaluation of efficacy in longitudinal IT studies, taking the differences in annual pollen counts into consideration. The model showed a significant beneficial role of pollen IT in rhinoconjunctivitis patients allergic to birch and grass pollen.


Asunto(s)
Desensibilización Inmunológica , Extractos Vegetales/administración & dosificación , Poaceae/inmunología , Polen/inmunología , Rinitis Alérgica Estacional/terapia , Árboles/inmunología , Adolescente , Adulto , Contaminación del Aire , Alérgenos/inmunología , Sesgo , Recuento de Células , Método Doble Ciego , Femenino , Humanos , Masculino , Persona de Mediana Edad , Extractos Vegetales/inmunología , Polen/citología , Rinitis Alérgica Estacional/etiología , Rinitis Alérgica Estacional/inmunología , Resultado del Tratamiento
2.
Allergy ; 54(5): 436-45, 1999 May.
Artículo en Inglés | MEDLINE | ID: mdl-10380774

RESUMEN

BACKGROUND: Serum specific IgE, basophil histamine release, and blood eosinophil parameters are associated with allergic rhinitis, but investigations of the relationship to the severity of allergic symptoms are few and conflicting. Our study aimed to investigate the seasonal changes in the following laboratory tests: specific IgE, basophil histamine release, eosinophil counts, and serum and plasma eosinophil cationic protein (ECP) and eosinophil protein X (EPX), and to analyze, in detail, the relationship of each individual test to the severity of symptoms in rhinitis patients allergic to both birch and grass pollen. METHODS: The above tests were performed on blood samples obtained from 49 allergic rhinitis patients during the birch-pollen season, during the grass-pollen season, and after the seasons. Symptom-medication diaries were filled in during both pollen seasons. We used partial least square (PLS) analysis to establish an optimal statistical link between the symptom score and medication and the laboratory tests, in an investigator-independent way. RESULTS: Increases in specific IgE, basophil histamine release, eosinophil counts, serum ECP and EPX, and plasma EPX were observed from the birch-pollen season to the grass-pollen season, followed by a decrease from the grass-pollen season to after the pollen seasons, except for the specific IgE. No seasonal changes in plasma ECP and total IgE were seen. The PLS analysis found a relationship between symptom score and medication and the aggregate laboratory tests (F-test value 40.2, correlation 0.34 for the cumulative relation). However, the variation in laboratory tests could explain only half of the total variation in symptoms and less than a quarter of the total variation in medication. The symptom score and, to a minor degree, medication were especially correlated with the basophil histamine-release results, with a decreasing relevance of specific IgE, eosinophil counts, total IgE, serum and plasma EPX, and serum ECP. Plasma ECP was not related to the symptom score and medication. CONCLUSIONS: A significant relationship between the severity of allergic rhinitis and various allergic inflammatory markers was found but could account for only a minor part of the variation in the patients' evaluation of their disease.


Asunto(s)
Basófilos/fisiología , Eosinófilos/fisiología , Mediadores de Inflamación/análisis , Rinitis Alérgica Estacional/inmunología , Ribonucleasas , Adolescente , Adulto , Proteínas Sanguíneas/análisis , Proteínas en los Gránulos del Eosinófilo , Neurotoxina Derivada del Eosinófilo , Femenino , Liberación de Histamina , Humanos , Inmunoglobulina E/sangre , Recuento de Leucocitos , Masculino , Persona de Mediana Edad , Polen/inmunología , Rinitis Alérgica Estacional/etiología , Rinitis Alérgica Estacional/patología , Estaciones del Año , Índice de Severidad de la Enfermedad
3.
Int Arch Allergy Appl Immunol ; 86(2): 225-33, 1988.
Artículo en Inglés | MEDLINE | ID: mdl-3391687

RESUMEN

This study investigates the correlation between the daily birch pollen counts, hay fever symptoms and medicine scores. Fifteen birch pollinosis patients were studied during two consecutive birch pollen seasons. All had a positive history for birch hay fever and a positive skin prick test, nasal provocation test and/or conjunctival provocation test to birch pollen. The patients recorded daily symptom and medicine scores during February through May for two seasons. According to nasal/conjunctival sensitivity and medicine consumption the group was divided into three groups: very sensitive, sensitive, and fairly sensitive. The mathematical calculations were based only on the results from the two most sensitive groups. The relationship between symptom scores and medicine scores as a function of the pollen load was nonlinear. A mathematical model was calculated. It was found that simply adding symptom scores and medicine scores to a total symptom/medication score was not meaningful as a basis for a quantitative analysis. It was further shown that the response caused by a given pollen load decays exponentially with time and that this decay had a characteristic half-life period of about 1-2 days indicating a long-lasting effect, i.e. contribution of the late allergic reaction to symptoms. Both groups showed the development of increased medicine intake during the season for a constant pollen load. This indicates the development of a higher sensitivity to birch pollen during the season. The overall response was divided into characteristic levels based on dose-response relationships, and pollen concentration intervals for forecasting purposes are suggested.


Asunto(s)
Polen , Rinitis Alérgica Estacional/epidemiología , Estaciones del Año , Estadística como Asunto , Árboles , Adolescente , Adulto , Dinamarca , Relación Dosis-Respuesta Inmunológica , Humanos , Persona de Mediana Edad , Modelos Teóricos , Análisis de Regresión , Rinitis Alérgica Estacional/diagnóstico , Rinitis Alérgica Estacional/tratamiento farmacológico
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