Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Más filtros

Bases de datos
Tipo del documento
País de afiliación
Intervalo de año de publicación
1.
Nat Biotechnol ; 28(5): 478-85, 2010 May.
Artículo en Inglés | MEDLINE | ID: mdl-20458318

RESUMEN

Kidney toxicity accounts both for the failure of many drug candidates as well as considerable patient morbidity. Whereas histopathology remains the gold standard for nephrotoxicity in animal systems, serum creatinine (SCr) and blood urea nitrogen (BUN) are the primary options for monitoring kidney dysfunction in humans. The transmembrane tubular protein kidney injury molecule-1 (Kim-1) was previously reported to be markedly induced in response to renal injury. Owing to the poor sensitivity and specificity of SCr and BUN, we used rat toxicology studies to compare the diagnostic performance of urinary Kim-1 to BUN, SCr and urinary N-acetyl-beta-D-glucosaminidase (NAG) as predictors of kidney tubular damage scored by histopathology. Kim-1 outperforms SCr, BUN and urinary NAG in multiple rat models of kidney injury. Urinary Kim-1 measurements may facilitate sensitive, specific and accurate prediction of human nephrotoxicity in preclinical drug screens. This should enable early identification and elimination of compounds that are potentially nephrotoxic.


Asunto(s)
Biomarcadores Farmacológicos/orina , Moléculas de Adhesión Celular/orina , Pruebas de Función Renal/métodos , Riñón , Acetilglucosaminidasa/orina , Animales , Biomarcadores Farmacológicos/metabolismo , Nitrógeno de la Urea Sanguínea , Moléculas de Adhesión Celular/genética , Moléculas de Adhesión Celular/metabolismo , Cisplatino/toxicidad , Creatinina/sangre , Ciclosporina/toxicidad , Evaluación Preclínica de Medicamentos , Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos , Gentamicinas/toxicidad , Histocitoquímica , Riñón/efectos de los fármacos , Riñón/lesiones , Pruebas de Función Renal/normas , Masculino , Análisis de Secuencia por Matrices de Oligonucleótidos , Curva ROC , Ratas , Ratas Sprague-Dawley , Ratas Wistar , Daño por Reperfusión , Tioacetamida/toxicidad
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA